Sánchez-Moya Teresa, López-Nicolás Rubén, Peso-Echarri Patricia, González-Bermúdez Carlos A, Frontela-Saseta Carmen
Department of Food Science and Nutrition, Faculty of Veterinary Sciences, Regional Campus of International Excellence Campus Mare Nostrum, University of Murcia, Murcia, Spain.
Front Nutr. 2024 Mar 27;11:1381125. doi: 10.3389/fnut.2024.1381125. eCollection 2024.
Inflammatory bowel disease (IBD) comprises a heterogeneous group of chronic diseases as ulcerative colitis (UC) and Crohn's disease (CD). IBD is the result of a dysregulation of intestinal homeostasis with a host's loss of tolerance toward normal enteric microflora. Plant-based extracts as phenolic compounds can play a role by modulating the intestinal inflammation response.
The antimicrobial activity of French maritime pine bark extract (PBE) and its phenolic constituents has been investigated in this study. Furthermore, the ability of PBE and phenolic compounds (caffeic acid, chlorogenic acid, ferulic acid, gallic acid and taxifolin) to modulate the microbiota has been assessed.
Phenolic compounds and PBE showed a great inhibitory effect on the pathogens growth at the highest concentration assessed (1.25 mg/mL). The growth of and were affected by the effect of caffeic acid and ferulic acid. Taxifolin showed a very strong activity against sp. (with a reduction ~98%). Gallic acid revealed antibacterial effect on at different concentrations. The inhibitory effect of PBE was highly significant on the growth of O157:H7. PBE, caffeic acid and chlorogenic acid seem to provide the greatest beneficial effect on the probiotic bacteria. However, the highest concentrations of taxifolin may have impaired the growth of beneficial microbiota.
Present findings could be of interest for considering PBE and/or its phenolic constituents as protectors against gastrointestinal disturbances which lead to ulcerative colitis and Crohn's disease.
炎症性肠病（IBD）包括一组异质性的慢性疾病，如溃疡性结肠炎（UC）和克罗恩病（CD）。IBD是肠道稳态失调的结果，宿主对正常肠道微生物群失去耐受性。植物提取物如酚类化合物可通过调节肠道炎症反应发挥作用。
本研究调查了法国滨海松树皮提取物（PBE）及其酚类成分的抗菌活性。此外，还评估了PBE和酚类化合物（咖啡酸、绿原酸、阿魏酸、没食子酸和花旗松素）调节微生物群的能力。
在评估的最高浓度（1.25mg/mL）下，酚类化合物和PBE对病原体生长表现出很强的抑制作用。咖啡酸和阿魏酸的作用影响了[具体菌种1]和[具体菌种2]的生长。花旗松素对[具体菌种3]表现出非常强的活性（减少约98%）。没食子酸在不同浓度下对[具体菌种4]显示出抗菌作用。PBE对O157:H7的生长抑制作用非常显著。PBE、咖啡酸和绿原酸似乎对益生菌提供了最大的有益作用。然而，花旗松素的最高浓度可能会损害有益微生物群的生长。
目前的研究结果可能有助于将PBE和/或其酚类成分视为预防导致溃疡性结肠炎和克罗恩病的胃肠道紊乱的保护剂。
