Singhal Khushboo, Gupta Shweta, Tiwari Sunita, Pinjar Mohammed Jaffer
Department of Physiology, Subharti Medical College, Meerut, IND.
Department of Physiology, Prasad Institute of Medical Sciences, Lucknow, IND.
Cureus. 2024 Mar 10;16(3):e55910. doi: 10.7759/cureus.55910. eCollection 2024 Mar.
This research was conducted to assess the effectiveness of red cell distribution width (RDW) as an indicator for pre-eclampsia (PE), a condition characterized by elevated blood pressure and the presence of protein in the urine occurring beyond the 20th week of pregnancy.
The case-control investigation spanned 10 months, following the acquisition of informed consent and the receipt of ethical clearance. The study sample comprised a total of 70 pregnant women, evenly divided into two groups: 35 cases of PE and 35 normotensive pregnant controls. Both the cases and controls provided 3 ml venous blood samples. The study employed a semi-automated three-part hematological analyzer to establish the baseline RDW for all individuals.
This study showed that the individuals with pre-eclampsia had a greater RDW compared to the healthy pregnant women. The observed difference was found to be statistically significant, with a p-value of 0.004. The receiver operating curve (ROC) analysis showed that RDW exhibited significant diagnostic accuracy in differentiating between cases and controls (area under the curve [AUC] = 0.71, P = 0.004) when employing a cut-off value of >= 18.25. The sensitivity was 80% and the specificity was 71.4%.
In contrast to other indicators of inflammation, RDW is a cost-effective and easily accessible biomarker that can be acquired from routine complete blood counts. It has the potential to be valuable in predicting and diagnosing pre-eclampsia.
本研究旨在评估红细胞分布宽度（RDW）作为子痫前期（PE）指标的有效性。子痫前期是一种在妊娠20周后出现血压升高和尿液中出现蛋白质的病症。
在获得知情同意并获得伦理批准后，病例对照研究持续了10个月。研究样本共包括70名孕妇，平均分为两组：35例子痫前期患者和35名血压正常的孕妇对照组。病例组和对照组均提供3毫升静脉血样本。该研究采用半自动三分群血液分析仪为所有个体建立RDW基线。
本研究表明，子痫前期患者的RDW高于健康孕妇。观察到的差异具有统计学意义，p值为0.004。受试者工作特征曲线（ROC）分析表明，当采用≥18.25的临界值时，RDW在区分病例组和对照组方面具有显著的诊断准确性（曲线下面积[AUC]=0.71，P=0.004）。敏感性为80%，特异性为71.4%。
与其他炎症指标相比，RDW是一种经济高效且易于获取的生物标志物，可从常规全血细胞计数中获得。它在预测和诊断子痫前期方面具有潜在价值。
