红细胞分布宽度与苏丹孕妇子痫前期无关。
Red blood cell distribution width is not correlated with preeclampsia among pregnant Sudanese women.
机构信息
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Khartoum, Khartoum, Sudan.
出版信息
Diagn Pathol. 2014 Feb 5;9:29. doi: 10.1186/1746-1596-9-29.
BACKGROUND
Preeclampsia is a leading cause of maternal and perinatal mortality worldwide. The exact etiology of preeclampsia is unknown, but the inflammatory process is postulated as one of the etiologies. Red blood cell distribution width (RDW) is a measure of anisocytosis (variation of red cell size) and is associated with hypertension and diabetic ketoacidosis. There are few data on the association between RDW and preeclampsia. This study aimed to investigate the association between RDW and preeclampsia.
METHODS
A case-control study was conducted at Khartoum Hospital, Sudan, during June to August 2012. Cases were women with preeclampsia and healthy women were controls. Sociodemographic characteristics, obstetrics, and clinical data were recorded. The complete blood count, including RDW, was measured using an automated hematology analyzer.
RESULTS
The cases and controls (65 women in each arm) were matched in their basic characteristics. There was no difference in the mean (SD) RDW between women with preeclampsia and controls (14.5 ± 1.8% vs. 14.4 ± 1.4%, P = 0.710). There was also no difference in the mean RDW between women with mild and severe preeclampsia (14.7 ± 1.9% vs. 13.9 ± 1.4%, P = 0.144. In logistic regression, there was no association between RDW and preeclampsia (OR = 0.9, CI = 0.7-1.1, P = 0.952).
CONCLUSIONS
RDW levels are not associated with the presence or severity of preeclampsia.
VIRTUAL SLIDES
The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1206247718115175.
背景
子痫前期是全球孕产妇和围产期死亡的主要原因。子痫前期的确切病因尚不清楚，但炎症过程被认为是其中一种病因。红细胞分布宽度（RDW）是红细胞大小不均（anisocytosis）的衡量指标，与高血压和糖尿病酮症酸中毒有关。关于 RDW 与子痫前期之间的关联，数据很少。本研究旨在探讨 RDW 与子痫前期之间的关联。
方法
这是一项在 2012 年 6 月至 8 月期间于苏丹喀土穆医院进行的病例对照研究。病例为子痫前期患者，对照组为健康女性。记录社会人口统计学特征、产科和临床数据。使用自动血液分析仪测量全血细胞计数，包括 RDW。
结果
病例组和对照组（每组 65 名女性）在基本特征上相匹配。子痫前期患者和对照组之间的平均（SD）RDW 无差异（14.5±1.8%对 14.4±1.4%，P=0.710）。轻度和重度子痫前期患者的平均 RDW 也无差异（14.7±1.9%对 13.9±1.4%，P=0.144）。在逻辑回归中，RDW 与子痫前期之间无关联（OR=0.9，CI=0.7-1.1，P=0.952）。
结论
RDW 水平与子痫前期的存在或严重程度无关。
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