Department of Biotechnology, Sharda School of Engineering and Technology, Sharda University, Greater Noida, Uttar Pradesh, India.
Division of Research & Innovation (DRI), School of Applied & Life Sciences, Uttaranchal University, Dehradun, Uttarakhand, India.
Aging Dis. 2024 Oct 1;15(5):2113-2135. doi: 10.14336/AD.2024.0322.
The diagnosis, treatment, and management of dementia provide significant challenges due to its chronic cognitive impairment. The complexity of this condition is further highlighted by the impact of gene-environment interactions. A recent strategy combines advanced genomics and precision medicine methods to explore the complex genetic foundations of dementia. Utilizing the most recent research in the field of neurogenetics, the importance of precise genetic data in explaining the variation seen in dementia patients can be investigated. Gene-environment interactions are important because they influence genetic susceptibilities and aid in the development and progression of dementia. Modified to each patient's genetic profile, precision medicine has the potential to detect groups at risk and make previously unheard-of predictions about the course of diseases. Precision medicine techniques have the potential to completely transform treatment and diagnosis methods. Targeted medications that target genetic abnormalities will probably appear, providing the possibility for more efficient and customized medical interventions. Investigating the relationship between genes and the environment may lead to preventive measures that would enable people to change their surroundings and minimize the risk of dementia, leading to the improved lifestyle of affected people. This paper provides a comprehensive overview of the genomic insights into dementia, emphasizing the pivotal role of precision medicine, and gene-environment interactions.
由于其慢性认知障碍,痴呆症的诊断、治疗和管理带来了巨大的挑战。基因-环境相互作用进一步突出了这种情况的复杂性。最近的一项策略结合了先进的基因组学和精准医学方法,探索痴呆症的复杂遗传基础。利用神经遗传学领域的最新研究,可以研究精确的遗传数据在解释痴呆症患者中观察到的变异性方面的重要性。基因-环境相互作用很重要,因为它们影响遗传易感性,并有助于痴呆症的发展和进展。精准医学可以根据每个患者的基因谱进行修改,有可能检测到处于危险中的群体,并对疾病的进程做出以前闻所未闻的预测。精准医学技术有可能彻底改变治疗和诊断方法。针对遗传异常的靶向药物可能会出现,为更有效和定制化的医疗干预提供可能性。研究基因与环境之间的关系可能会导致预防措施,使人们能够改变周围环境,最大限度地降低痴呆症的风险,从而改善受影响人群的生活方式。本文全面概述了痴呆症的基因组见解,强调了精准医学和基因-环境相互作用的关键作用。