人类4号染色体上与β-干扰素相关的DNA。

Interferon-beta-related DNA on human chromosome 4.

作者信息

Sagar A D, Sehgal P B, May L T, Slate D L, Shulman L, Barker P E, Ruddle F H

出版信息

Somat Cell Mol Genet. 1985 Jul;11(4):403-8. doi: 10.1007/BF01534418.

Abstract

A DNA subclone (pPE-4000) derived from the lambda B4 interferon-beta-related human genomic DNA clone was used as a probe in blot-hybridization experiments of DNA from a panel of human-rodent somatic cell hybrids containing overlapping subsets of human chromosomes. The DNA hybridization experiments showed that the lambda B4 IFN-beta locus is localized to human chromosome 4. A provisional regional assignment to 4q12-qter was also obtained. Thus available hybridization data implicate human chromosomes 2, 4, and 9 in the human IFN-beta system while the available biological data also implicated human chromosome 5.

摘要

一个源自λB4干扰素-β相关人类基因组DNA克隆的DNA亚克隆（pPE - 4000）被用作探针，对一组包含人类染色体重叠子集的人 - 啮齿动物体细胞杂种的DNA进行印迹杂交实验。DNA杂交实验表明，λB4干扰素-β基因座定位于人类4号染色体。还获得了其在4q12 - qter区域的初步定位。因此，现有的杂交数据表明人类2号、4号和9号染色体参与了人类干扰素-β系统，而现有的生物学数据也表明人类5号染色体与之有关。