人类免疫干扰素基因位于第12号染色体上。
Human immune interferon gene is located on chromosome 12.
作者信息
Naylor S L, Sakaguchi A Y, Shows T B, Law M L, Goeddel D V, Gray P W
出版信息
J Exp Med. 1983 Mar 1;157(3):1020-7. doi: 10.1084/jem.157.3.1020.
Abstract
A cDNA clone for human immune interferon (IFN-gamma) gene sequences, plasmid p69, was used to chromosomally map the IFN-gamma gene by detecting human IFN-gamma gene sequences in DNA isolated from human-rodent somatic cell hybrids. We were able to map the IFN-gamma gene by correlating the human chromosomes present in these hybrids with the human specific 8.8 and 2.0 kilobase pair fragments produced by EcoRI digestion of genomic DNA. Southern blot analysis of 37 hybrid cell lines indicated that the gene for IFN-gamma was on human chromosome 12. A hybrid containing a portion of chromosome 12 localized the IFN-gamma gene to the p1205 leads to qter region.
摘要
利用人免疫干扰素（IFN-γ）基因序列的cDNA克隆质粒p69，通过检测从人-啮齿动物体细胞杂种中分离出的DNA中的人IFN-γ基因序列，对IFN-γ基因进行染色体定位。我们通过将这些杂种中存在的人类染色体与基因组DNA经EcoRI酶切产生的8.8和2.0千碱基对的人特异性片段相关联，从而对IFN-γ基因进行定位。对37个杂种细胞系的Southern印迹分析表明，IFN-γ基因位于人类12号染色体上。一个含有12号染色体一部分的杂种将IFN-γ基因定位到了p1205至qter区域。
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本文引用的文献
1
Structure of a chromosomal gene for human interferon beta.人干扰素β基因的结构。
Proc Natl Acad Sci U S A. 1981 Sep;78(9):5305-9. doi: 10.1073/pnas.78.9.5305.
2
Similar amino acid sequences: chance or common ancestry?相似的氨基酸序列：偶然因素还是共同祖先？
Science. 1981 Oct 9;214(4517):149-59. doi: 10.1126/science.7280687.
3
The structure and evolution of the human beta-globin gene family.人类β-珠蛋白基因家族的结构与进化
Cell. 1980 Oct;21(3):653-68. doi: 10.1016/0092-8674(80)90429-8.
4
Mapping the human genome, cloned genes, DNA polymorphisms, and inherited disease.绘制人类基因组图谱、克隆基因、DNA多态性及遗传性疾病研究。
Adv Hum Genet. 1982;12:341-452. doi: 10.1007/978-1-4615-8315-8_5.
5
Regional mapping of the gene coding for enolase-2 on human chromosome 12.人12号染色体上烯醇化酶-2编码基因的区域定位。
J Cell Sci. 1982 Feb;53:245-54. doi: 10.1242/jcs.53.1.245.
6
The molecular genetics of human hemoglobins.人类血红蛋白的分子遗传学。
Annu Rev Genet. 1980;14:145-78. doi: 10.1146/annurev.ge.14.120180.001045.
7
Clustering of leukocyte and fibroblast interferon genes of human chromosome 9.人类9号染色体上白细胞和成纤维细胞干扰素基因的聚类
Science. 1982 Oct 22;218(4570):373-4. doi: 10.1126/science.6181564.
8
Nucleotide sequence of a portion of human chromosome 9 containing a leukocyte interferon gene cluster.包含白细胞干扰素基因簇的人类9号染色体部分的核苷酸序列。
J Mol Biol. 1982 Apr 15;156(3):467-86. doi: 10.1016/0022-2836(82)90261-3.
9
Structure of the human immune interferon gene.人类免疫干扰素基因的结构。
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10
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