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用于预防慢性应激引起的抑郁的微生物仿生纳米芳香药物。

Microbial bionic nano-aromatic drugs for prevention of depression induced by chronic stress.

机构信息

College of Pharmacy, Heze University, Heze, 274015, PR China.

State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, PR China.

出版信息

J Nanobiotechnology. 2024 Apr 12;22(1):173. doi: 10.1186/s12951-024-02382-y.

DOI:10.1186/s12951-024-02382-y
PMID:38609944
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11015588/
Abstract

Depression is a mood disorder mainly clinically characterized by significant and persistent low spirits. Chronic stress is the leading cause of depression. However, traditional medicine has severe side effects in treating depression, ineffective treatment, and easy recurrence. Therefore, it is of great significance to prevent depression in the environment of chronic stress. In this study, aromatherapy was used for the prevention of depression. To solve the defects of intense volatility and inconvenience in using essential oils, we designed bionic nano-aromatic drugs and adhered them to the wallpaper. Inspired by the moldy wallpaper, we successively prepared the morphology-bionic nano-aromatic drugs, the function-bionic nano-aromatic drugs, and the bionic plus nano-aromatic drugs by referring to the morphology of microorganisms and substances in bacterial biofilms. Bionic nano-aromatic drugs remarkably promoted their adhesion on wallpaper. Molecular dynamics simulation explored its molecular mechanism. The essential oils, which were slowly released from the bionic nano-aromatic drugs, showed excellent biosecurity and depression prevention. These sustainedly released essential oils could significantly increase monoamine neurotransmitters in the brain under a chronic stress environment and had excellent neuroprotection. Besides, the bionic nano-aromatic drugs with simple preparation process and low cost had excellent application potential.

摘要

抑郁症是一种心境障碍，主要临床特征为显著且持续的情绪低落。慢性应激是导致抑郁症的主要原因。然而，传统医学在治疗抑郁症方面存在严重的副作用、疗效不佳且容易复发。因此，在慢性应激环境下预防抑郁症具有重要意义。本研究采用芳香疗法预防抑郁症。为了解决精油挥发性强、使用不便的缺陷，我们设计了仿生纳米芳香药物并将其附着在壁纸上。受发霉壁纸的启发，我们通过参考微生物和细菌生物膜中物质的形态，先后制备了形态仿生纳米芳香药物、功能仿生纳米芳香药物和仿生加纳米芳香药物。仿生纳米芳香药物显著促进了它们在壁纸上的附着。分子动力学模拟探索了其分子机制。从仿生纳米芳香药物中缓慢释放的精油表现出优异的生物安全性和预防抑郁的作用。在慢性应激环境下，这些持续释放的精油可显著增加大脑中的单胺神经递质，具有出色的神经保护作用。此外，该仿生纳米芳香药物具有制备工艺简单、成本低的优点，具有出色的应用潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ba7/11015588/dc6afefd29a7/12951_2024_2382_Fig7_HTML.jpg
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