Sagliocchi Serena, Schiano Elisabetta, Acampora Lucia, Iannuzzo Fortuna, Cicatiello Annunziata Gaetana, Miro Caterina, Nappi Annarita, Restolfer Federica, Stornaiuolo Mariano, Zarrilli Stefano, Guerra Fabrizia, Tenore Gian Carlo, Dentice Monica, Novellino Ettore
Department of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Napoli, Italy.
Inventia Biotech-Healthcare Food Research Center s.r.l., Strada Statale Sannitica KM 20.700, 81020 Caserta, Italy.
Foods. 2024 Dec 27;14(1):48. doi: 10.3390/foods14010048.
Adipose tissue, particularly white adipose tissue (WAT), plays a central role in energy storage and metabolic regulation. Excess WAT, especially visceral fat, is strongly linked to metabolic disorders such as obesity and type 2 diabetes. The browning of WAT, whereby white fat cells acquire characteristics of brown adipose tissue (BAT) with enhanced thermogenic capacity, represents a promising strategy to enhance metabolic health. In this study, we investigated the effects of chronic supplementation with an infusion based on lyophilized, thin nectarines rich in abscisic acid (ABA), named AbaComplex, on promoting browning of WAT and activating BAT in mice. Over 30 days, C57BL/6 mice were treated with the ABA-rich infusion, and various metabolic and molecular parameters were assessed. The results showed that the AbaComplex significantly increased the expression of browning markers, such as UCP1 and PGC1-α, in both visceral and subcutaneous WAT. Additionally, mitochondrial biogenesis and function were enhanced, evidenced by elevated mitochondrial DNA content and activity. The treatment also reduced the weight of WAT (both visceral and subcutaneous) and BAT and significantly improved glucose uptake in WAT via upregulation of GLUT4, suggesting enhanced insulin sensitivity. Overall, the pronounced browning effect in WAT underscores the potential of AbaComplex as a natural approach for combating obesity and improving metabolic health.
脂肪组织，尤其是白色脂肪组织（WAT），在能量储存和代谢调节中起着核心作用。过量的WAT，尤其是内脏脂肪，与肥胖和2型糖尿病等代谢紊乱密切相关。WAT的褐变，即白色脂肪细胞获得具有增强产热能力的棕色脂肪组织（BAT）的特征，是增强代谢健康的一种有前景的策略。在本研究中，我们研究了长期补充一种基于富含脱落酸（ABA）的冻干薄油桃的输注液（名为AbaComplex）对促进小鼠WAT褐变和激活BAT的影响。在30天内，用富含ABA的输注液处理C57BL/6小鼠，并评估各种代谢和分子参数。结果表明，AbaComplex显著增加了内脏和皮下WAT中褐变标志物如UCP1和PGC1-α的表达。此外，线粒体生物发生和功能得到增强，线粒体DNA含量和活性升高证明了这一点。该处理还减轻了WAT（内脏和皮下）和BAT的重量，并通过上调GLUT4显著改善了WAT中的葡萄糖摄取，表明胰岛素敏感性增强。总体而言，WAT中明显的褐变效应突出了AbaComplex作为对抗肥胖和改善代谢健康的天然方法的潜力。
