Beighton D
Arch Oral Biol. 1985;30(5):403-7. doi: 10.1016/0003-9969(85)90067-6.
The colonization of the mouth by the two Actinomyces species, postulated to be members of a basic plaque flora, was studied in 27 consecutively-born neonatal monkeys. Bacteria adherent to the tongue and cheek surfaces were sampled from each monkey soon after birth (mean age = 3.2 days). The tongue and cheek surfaces and the labial surfaces of the incisor teeth were sampled at 4, 8 and 12 weeks of age. From only one neonatal sample were Actinomyces species isolated. By 4 weeks of age, the incisor teeth are partially erupted and, from teeth erupted more than 1 mm, A. naeslundii was frequently isolated and its proportion increased between 4 and 8 weeks on all surfaces sampled. At 4, 8 and 12 weeks, the proportion of A. naeslundii on the incisor teeth was greater than on the mucosal surfaces. The isolation rate of A. viscosus was low in these neonates, but it was isolated from each of 6 juvenile monkeys fed a starch diet. In the 6 juvenile monkeys, the proportion of A. viscosus decreased following the introduction of a sucrose-containing diet, whereas the proportion of A. naeslundii on the teeth increased. The early establishment of A. naeslundii and, to a lesser extent, A. viscosus in the dental plaque of neonatal monkeys fed exclusively by their mothers suggests that members of a basic plaque flora may be those bacteria establishing in the plaque during the period of breast-feeding.
在27只连续出生的新生猴中，研究了两种放线菌在口腔中的定植情况，这两种放线菌被假定为基本菌斑菌群的成员。在每只猴子出生后不久（平均年龄 = 3.2天），采集其舌面和颊面附着的细菌样本。在4、8和12周龄时，采集舌面、颊面以及切牙的唇面样本。仅从一个新生猴样本中分离出了放线菌。到4周龄时，切牙部分萌出，从萌出超过1毫米的牙齿中，经常分离出内氏放线菌，并且在所有采样表面上，其比例在4至8周之间增加。在4、8和12周时，切牙上内氏放线菌的比例高于粘膜表面。在这些新生猴中，黏性放线菌的分离率较低，但从6只喂食淀粉饮食的幼年猴中均分离出了该菌。在这6只幼年猴中，引入含蔗糖饮食后，黏性放线菌的比例下降，而牙齿上内氏放线菌的比例增加。仅由母亲喂养的新生猴牙菌斑中内氏放线菌的早期定植，以及在较小程度上黏性放线菌的早期定植，表明基本菌斑菌群的成员可能是在母乳喂养期间在菌斑中定植的那些细菌。
