• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Molecular heterogeneity of quiescent melanocyte stem cells revealed by single-cell RNA-sequencing.单细胞 RNA 测序揭示静止黑素细胞干细胞的分子异质性。
Pigment Cell Melanoma Res. 2024 Jul;37(4):480-495. doi: 10.1111/pcmr.13169. Epub 2024 Apr 13.
2
Molecular heterogeneity of quiescent melanocyte stem cells revealed by single-cell RNA-sequencing.单细胞RNA测序揭示静止期黑素细胞干细胞的分子异质性
bioRxiv. 2023 Dec 20:2023.12.19.571712. doi: 10.1101/2023.12.19.571712.
3
Human Infrapatellar Fat Pad Mesenchymal Stem Cell-derived Extracellular Vesicles Purified by Anion Exchange Chromatography Suppress Osteoarthritis Progression in a Mouse Model.阴离子交换层析法纯化的人髌下脂肪垫间充质干细胞来源细胞外囊泡抑制骨关节炎在小鼠模型中的进展。
Clin Orthop Relat Res. 2024 Jul 1;482(7):1246-1262. doi: 10.1097/CORR.0000000000003067. Epub 2024 Apr 19.
4
Dynamic regulation of chromatin accessibility during melanocyte stem cell activation.黑素细胞干细胞激活过程中染色质可及性的动态调控。
Pigment Cell Melanoma Res. 2023 Nov;36(6):531-541. doi: 10.1111/pcmr.13112. Epub 2023 Jul 18.
5
A single-cell transcriptomic atlas of human lens epithelium: identification and functional insights into lens stem/progenitor cells.人类晶状体上皮细胞的单细胞转录组图谱：晶状体干/祖细胞的鉴定及功能见解
Stem Cell Res Ther. 2025 Jul 1;16(1):333. doi: 10.1186/s13287-025-04436-w.
6
Comprehensive single-cell chromatin and transcriptomic profiling of peripheral immune cells in nonsegmental vitiligo.非节段性白癜风外周免疫细胞的单细胞染色质和转录组综合分析
Br J Dermatol. 2025 Jun 20;193(1):115-124. doi: 10.1093/bjd/ljaf041.
7
Artificial intelligence approaches for tumor phenotype stratification from single-cell transcriptomic data.基于单细胞转录组数据的肿瘤表型分层的人工智能方法
Elife. 2025 Jun 13;13:RP98469. doi: 10.7554/eLife.98469.
8
Falls prevention interventions for community-dwelling older adults: systematic review and meta-analysis of benefits, harms, and patient values and preferences.社区居住的老年人跌倒预防干预措施：系统评价和荟萃分析的益处、危害以及患者的价值观和偏好。
Syst Rev. 2024 Nov 26;13(1):289. doi: 10.1186/s13643-024-02681-3.
9
Deciphering cholangiocarcinoma heterogeneity and specific progenitor cell niche of extrahepatic cholangiocarcinoma at single-cell resolution.以单细胞分辨率解析肝外胆管癌的胆管癌异质性和特定祖细胞生态位。
J Hematol Oncol. 2025 Jun 23;18(1):66. doi: 10.1186/s13045-025-01716-z.
10
Lnc056 Enhances Hair Follicle Stem Cells Proliferation by Binding Transcription Factor HNRNPUL1 to Up-Regulate TRIP6 Expression.长链非编码RNA 056通过结合转录因子HNRNPUL1上调TRIP6表达来增强毛囊干细胞增殖。
FASEB J. 2025 Jun 30;39(12):e70764. doi: 10.1096/fj.202500381R.

引用本文的文献

1
Cellular and Molecular Basis of Environment-Induced Color Change in a Tree Frog.树蛙环境诱导颜色变化的细胞和分子基础。
Animals (Basel). 2024 Dec 1;14(23):3472. doi: 10.3390/ani14233472.
2
Quiescence and aging of melanocyte stem cells and a novel association with programmed death-ligand 1.黑素细胞干细胞的静止与衰老以及与程序性死亡配体1的新关联。
iScience. 2024 Sep 12;27(10):110908. doi: 10.1016/j.isci.2024.110908. eCollection 2024 Oct 18.

本文引用的文献

1
Dynamic regulation of chromatin accessibility during melanocyte stem cell activation.黑素细胞干细胞激活过程中染色质可及性的动态调控。
Pigment Cell Melanoma Res. 2023 Nov;36(6):531-541. doi: 10.1111/pcmr.13112. Epub 2023 Jul 18.
2
Dedifferentiation maintains melanocyte stem cells in a dynamic niche.去分化使黑素细胞干细胞在一个动态的龛位中维持。
Nature. 2023 Apr;616(7958):774-782. doi: 10.1038/s41586-023-05960-6. Epub 2023 Apr 19.
3
Pigment cell progenitor heterogeneity and reiteration of developmental signaling underlie melanocyte regeneration in zebrafish.色素细胞祖细胞的异质性和发育信号的重复是斑马鱼黑素细胞再生的基础。
Elife. 2023 Apr 6;12:e78942. doi: 10.7554/eLife.78942.
4
Characterization of a melanocyte progenitor population in human interfollicular epidermis.人毛囊间表皮中黑素细胞祖细胞群体的特征。
Cell Rep. 2022 Mar 1;38(9):110419. doi: 10.1016/j.celrep.2022.110419.
5
Generalized and scalable trajectory inference in single-cell omics data with VIA.使用 VIA 对单细胞组学数据进行广义和可扩展的轨迹推断。
Nat Commun. 2021 Sep 20;12(1):5528. doi: 10.1038/s41467-021-25773-3.
6
Phenotypic plasticity of melanocytes derived from human adult skin.源自成人皮肤的黑素细胞的表型可塑性。
Pigment Cell Melanoma Res. 2022 Jan;35(1):38-51. doi: 10.1111/pcmr.13012. Epub 2021 Aug 31.
7
Direct Interaction of Sox10 With Cadherin-19 Mediates Early Sacral Neural Crest Cell Migration: Implications for Enteric Nervous System Development Defects.Sox10 与钙黏蛋白-19 的直接相互作用介导早期荐颅神经嵴细胞迁移：对肠神经系统发育缺陷的影响。
Gastroenterology. 2022 Jan;162(1):179-192.e11. doi: 10.1053/j.gastro.2021.08.029. Epub 2021 Aug 21.
8
Nerve-associated Schwann cell precursors contribute extracutaneous melanocytes to the heart, inner ear, supraorbital locations and brain meninges.神经相关雪旺细胞前体细胞可向心脏、内耳、眶上位置和脑膜贡献表皮外黑素细胞。
Cell Mol Life Sci. 2021 Aug;78(16):6033-6049. doi: 10.1007/s00018-021-03885-9. Epub 2021 Jul 18.
9
Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation.人核糖核酸酶 1 可作为 Ephrin A4 受体的分泌配体，并诱导乳腺癌起始。
Nat Commun. 2021 May 13;12(1):2788. doi: 10.1038/s41467-021-23075-2.
10
Regulation of PD-L1 expression in the tumor microenvironment.肿瘤微环境中 PD-L1 表达的调控。
J Hematol Oncol. 2021 Jan 7;14(1):10. doi: 10.1186/s13045-020-01027-5.

单细胞 RNA 测序揭示静止黑素细胞干细胞的分子异质性。

Molecular heterogeneity of quiescent melanocyte stem cells revealed by single-cell RNA-sequencing.

机构信息

Department of Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.

出版信息

Pigment Cell Melanoma Res. 2024 Jul;37(4):480-495. doi: 10.1111/pcmr.13169. Epub 2024 Apr 13.

DOI:10.1111/pcmr.13169
PMID:38613320
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11178447/
Abstract

Melanocyte stem cells (McSCs) of the hair follicle are a rare cell population within the skin and are notably underrepresented in whole-skin, single-cell RNA sequencing (scRNA-seq) datasets. Using a cell enrichment strategy to isolate KIT+/CD45- cells from the telogen skin of adult female C57BL/6J mice, we evaluated the transcriptional landscape of quiescent McSCs (qMcSCs) at high resolution. Through this evaluation, we confirmed existing molecular signatures for qMcCS subpopulations (e.g., Kit+, Cd34+/-, Plp1+, Cd274+/-, Thy1+, Cdh3+/-) and identified novel qMcSC subpopulations, including two that differentially regulate their immune privilege status. Within qMcSC subpopulations, we also predicted melanocyte differentiation potential, neural crest potential, and quiescence depth. Taken together, the results demonstrate that the qMcSC population is heterogeneous and future studies focused on investigating changes in qMcSCs should consider changes in subpopulation composition.

摘要

毛囊黑素细胞干细胞（McSCs）是皮肤中一种罕见的细胞群体，在全皮肤单细胞 RNA 测序（scRNA-seq）数据集中明显代表性不足。我们使用细胞富集策略从成年雌性 C57BL/6J 小鼠的休止期皮肤中分离出 KIT+/CD45-细胞，以高分辨率评估静止 McSCs（qMcSCs）的转录组图谱。通过这项评估，我们证实了 qMcCS 亚群的现有分子特征（例如，Kit+、Cd34+/-、Plp1+、Cd274+/-、Thy1+、Cdh3+/-），并鉴定了新的 qMcSC 亚群，包括两个可调节其免疫特权状态的亚群。在 qMcSC 亚群中，我们还预测了黑素细胞分化潜能、神经嵴潜能和静止深度。总之，这些结果表明 qMcSC 群体是异质的，未来专注于研究 qMcSCs 变化的研究应考虑亚群组成的变化。