Kesaniemi Y A, Grundy S M
Arteriosclerosis. 1983 Jan-Feb;3(1):40-6. doi: 10.1161/01.atv.3.1.40.
The turnover rates of low density lipoprotein-apolipoprotein (apoLDL) were determined in eight men with coronary heart disease (CHD) and seven men matched for age, weight, and plasma lipid levels who were used for controls. The CHD patients were normocholesterolemic (plasma cholesterol = 204 +/- 8 mg/dl sem) as were the control subjects (227 +/- 15 mg/dl). The concentrations of plasma LDL cholesterol and apoLDL were similar for the two groups. In contrast, the synthetic rates of apoLDL were higher in the CHD patients (20.0 +/- 1.8 mg/kg/day) than in the controls (12.9 +/- 1.1 mg/kg/day) (p less than 0.01). The ratios of protein-to-cholesterol in LDL averaged 19% higher in the CHD patients. These patients with CHD maintained normal LDL levels despite an over-production of apoLDL because of an increased capacity for LDL removal; their fractional catabolic rates of apoLDL averaged 43% higher than those of the controls. These findings indicate that some patients with CHD have abnormalities in the turnover of apoLDL, even with normal concentrations of LDL; these abnormalities may contribute to accelerated atherosclerosis.
在8名冠心病（CHD）男性患者以及7名年龄、体重和血脂水平与之匹配的男性对照者中，测定了低密度脂蛋白 - 载脂蛋白（apoLDL）的周转率。冠心病患者和对照者的血浆胆固醇水平均正常（冠心病患者：204±8mg/dl标准误；对照者：227±15mg/dl）。两组的血浆低密度脂蛋白胆固醇和apoLDL浓度相似。相比之下，冠心病患者中apoLDL的合成率（20.0±1.8mg/kg/天）高于对照组（12.9±1.1mg/kg/天）（p<0.01）。冠心病患者中低密度脂蛋白的蛋白质与胆固醇的比率平均高出19%。尽管apoLDL产生过多，但这些冠心病患者由于低密度脂蛋白清除能力增强，仍能维持正常的低密度脂蛋白水平；他们的apoLDL分数分解代谢率平均比对照组高43%。这些发现表明，一些冠心病患者即使低密度脂蛋白浓度正常，其apoLDL的周转率也存在异常；这些异常可能会导致动脉粥样硬化加速。
