Tatarinova Olga S, Furness Caroline L, Borman Andrew M, Barber Joy, Muthialu Nagarajan, Ferreras-Antolin Laura
Oak Centre for Children and Young People, The Royal Marsden NHS Foundation Trust, Downs Road, Sutton, SM2 5PT, United Kingdom.
UKHSA National Mycology Reference Laboratory, Southmead Hospital, Bristol, BS10 5NB, United Kingdom.
Med Mycol Case Rep. 2024 Apr 4;44:100645. doi: 10.1016/j.mmcr.2024.100645. eCollection 2024 Jun.
is a known cause of fungal infection in humans and animals. It is found to be more refractory to antifungal treatment in comparison to other species. With this report we present a case of proven invasive infection with in a child with chronic myeloid leukaemia after haematopoietic stem cell transplant. The patient received several lines of antifungal therapy including dual therapy appropriate to the antifungal susceptibility profile with progression of the invasive fungal disease requiring left lung upper lobe lobectomy. The case emphasizes the importance of early biopsy with antifungal susceptibility testing for targeted therapy and demonstrates the potential requirement for surgical management in addition to appropriate antifungal treatment.
是人和动物真菌感染的已知病因。与其他物种相比，它对抗真菌治疗更具难治性。通过本报告，我们呈现了一例造血干细胞移植后慢性髓系白血病患儿确诊为侵袭性感染的病例。患者接受了多线抗真菌治疗，包括根据抗真菌药敏结果进行的双联治疗，但侵袭性真菌病仍进展，需要进行左肺上叶肺叶切除术。该病例强调了早期活检及抗真菌药敏试验对靶向治疗的重要性，并证明了除适当的抗真菌治疗外，手术管理的潜在必要性。
