Deka Bimalendu, Kalita Rima, Bhatia Dinesh, Mishra Animesh
Department of Biomedical Engineering, North Eastern Hill University, Shillong, 793022, Meghalaya, India.
Department of Cardiology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, 793018, Meghalaya, India.
Sens Int. 2020;1:100004. doi: 10.1016/j.sintl.2020.100004. Epub 2020 Apr 9.
In human history, the paper has long been used as a platform to record and preserve information. However, over the decades, paper has found its application in Biomedical Sciences, too. Both paper-based microfluidic devices (μPADs) and paper-based cultures and scaffolds have shown immense potential to be used as a sensor as well as a supporting material for in vitro tissue engineering. μPADs can be used to perform low-cost and fast biomolecular assays at Point-Of-Care (POC). They are being used to detect various biomarkers like viral proteins, metabolites, oncogenes, and antigens; and conditions like Venous Thromboembolism (VTE). On the other hand, the paper has also been used to develop paper-based 3D cultures and scaffolds to test drugs, and monitor cytotoxic effects in vitro cell microenvironments and also as implantable tissues. In this review, we intend to enumerate the development in the field of μPADs, paper-based cell cultures, and paper-based scaffolds and their plethora of applications over the last decade.
在人类历史上，纸张长期以来一直被用作记录和保存信息的平台。然而，在过去几十年里，纸张在生物医学科学领域也有了应用。基于纸张的微流控装置（μPADs）以及基于纸张的培养物和支架，都显示出了作为传感器以及用于体外组织工程的支撑材料的巨大潜力。μPADs可用于在护理点（POC）进行低成本、快速的生物分子检测。它们被用于检测各种生物标志物，如病毒蛋白、代谢物、癌基因和抗原；以及诸如静脉血栓栓塞（VTE）等病症。另一方面，纸张也被用于开发基于纸张的3D培养物和支架，以测试药物，并监测体外细胞微环境中的细胞毒性作用，还可作为可植入组织。在这篇综述中，我们打算列举过去十年中μPADs、基于纸张的细胞培养物和基于纸张的支架领域的发展及其众多应用。
