Rubio Herrera Miguel A, Bretón Lesmes Irene
Servicio de Endocrinología y Nutrición, Hospital Clínico San Carlos. IDISSC. Facultad de Medicina, Universidad Complutense, Madrid, España.
Servicio de Endocrinología y Nutrición, Hospital Universitario Gregorio Marañón. Facultad de Medicina, Universidad Complutense, Madrid, España.
Endocrinol Diabetes Nutr. 2021 Feb;68(2):123-129. doi: 10.1016/j.endinu.2020.10.001. Epub 2020 Oct 21.
Obesity is a chronic disease that leads to an increased risk of mortality and morbidity, and the impact of the COVID-19 pandemic may create a new health challenge. There is clear evidence showing that some biological and social factors associated with obesity involve an increased risk of COVID-19 infection, hospitalization, and greater severity compared to people with normal weight. Undoubtedly, obesity involves a low-grade proinflammatory state that produces a dysregulation of the immune system that compromises its ability to respond to respiratory infection by COVID-19 and so produces a worsening of the disease. In this review, the main epidemiological and pathophysiological data that associate obesity with COVID-19 are described.
肥胖是一种慢性疾病，会导致死亡和发病风险增加，而新冠疫情的影响可能带来新的健康挑战。有明确证据表明，与肥胖相关的一些生物学和社会因素会使感染新冠病毒、住院的风险增加，且与体重正常者相比病情更严重。毫无疑问，肥胖涉及一种低度炎症状态，会导致免疫系统失调，损害其应对新冠病毒引起的呼吸道感染的能力，从而使病情恶化。在这篇综述中，描述了将肥胖与新冠病毒相关联的主要流行病学和病理生理学数据。
