Clin Lab. 2024 Apr 1;70(4). doi: 10.7754/Clin.Lab.2023.230922.
A typical non-neoplastic connective tissue proliferations called a pyogenic granuloma. A vascular adhesion molecule used to assess angiogenesis is the CD34 marker. The primary memberof a family of growth factors, VEGF helps in generating and maintaining the lymphatic and blood circulation systems.
The aim of the study was to know the correlation between VEGF and CD34 protein marker and pyogenic granuloma.
Thirty-one formalin fixed paraffin embedded (FFPE) blocks were taken from female pyogenic granuloma patients ranging in age from 29 to 70. The IHC was used to identify VEGF and CD34 expression in the cytoplasm of the cells.
Seventeenout of 31 patients had VEGF positive expression. Twenty-sixout of 31 had CD34 positive expression and 5 with no expression (negative expression). Brown-stained cytoplasm showed high VEGF and CD34 expression, whereas blue stained cytoplasm showed no VEGF and CD34 expression in these cells.
The results suggest the role of suchbiomarkers in the oral pyogenic granuloma pathogenesis, and it appears that CD34 and VEGF are valuable biomarkers in evaluating vascular and inflammatory diseases like pyogenic granuloma.
一种典型的非肿瘤性结缔组织增生，称为化脓性肉芽肿。一种用于评估血管生成的血管黏附分子是 CD34 标志物。VEGF 是生长因子家族的主要成员，有助于生成和维持淋巴和血液循环系统。
本研究旨在了解 VEGF 和 CD34 蛋白标志物与化脓性肉芽肿之间的相关性。
从年龄在 29 岁至 70 岁之间的女性化脓性肉芽肿患者中取出 31 个福尔马林固定石蜡包埋（FFPE）块。免疫组织化学用于鉴定细胞细胞质中的 VEGF 和 CD34 表达。
31 名患者中有 17 名 VEGF 阳性表达。31 名中有 26 名 CD34 阳性表达，5 名无表达（阴性表达）。棕褐色染色的细胞质显示出高 VEGF 和 CD34 表达，而这些细胞的蓝色细胞质则没有 VEGF 和 CD34 表达。
这些结果表明了这些生物标志物在口腔化脓性肉芽肿发病机制中的作用，并且 CD34 和 VEGF 似乎是评估化脓性肉芽肿等血管和炎症性疾病的有价值的生物标志物。
