Baron M
Acta Psychiatr Scand Suppl. 1985;319:85-92. doi: 10.1111/j.1600-0447.1985.tb08525.x.
Despite the evidence for genetic factors in schizophrenia, the underlying hereditary defect is unknown. The author reviews recent advances in genetic research methodologies and discusses their strengths and limitations. He concludes that in the face of genetic heterogeneity current models of segregation analysis are not likely to unravel the mode of inheritance of schizophrenia. The author underscores the potential contribution of both molecular genetics (as a means to generate DNA markers) and studies with biologic vulnerability traits to identifying and quantitating the genetic component in the transmission of schizophrenia.
尽管有证据表明精神分裂症存在遗传因素，但其潜在的遗传缺陷仍不明确。作者回顾了遗传研究方法的最新进展，并讨论了它们的优点和局限性。他得出结论，面对遗传异质性，当前的分离分析模型不太可能揭示精神分裂症的遗传模式。作者强调了分子遗传学（作为产生DNA标记的手段）和生物易感性特征研究在识别和量化精神分裂症传递中的遗传成分方面的潜在贡献。
