Faculty of Medicine, Kermanshah University of Medical Science, Kermanshah, Iran.
Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran; Universal Scientific Education and Research Network (USERN) Office, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Tissue Cell. 2024 Jun;88:102373. doi: 10.1016/j.tice.2024.102373. Epub 2024 Apr 9.
Cellular and molecular alterations associated with hearing loss are now better understood with advances in molecular biology. These changes indicate the participation of distinct damage and stress pathways that are unlikely to be fully addressed by conventional pharmaceutical treatment. Sensorineural hearing loss is a common and debilitating condition for which comprehensive pharmacologic intervention is not available. The complex and diverse molecular pathology that underlies hearing loss currently limits our ability to intervene with small molecules. The present review focuses on the potential for the use of extracellular vesicles in otology. It examines a variety of inner ear diseases and hearing loss that may be treatable using exosomes (EXOs). The role of EXOs as carriers for the treatment of diseases related to the inner ear as well as EXOs as biomarkers for the recognition of diseases related to the ear is discussed.
随着分子生物学的进步，与听力损失相关的细胞和分子变化现在得到了更好的理解。这些变化表明不同的损伤和应激途径的参与，而传统的药物治疗不太可能完全解决这些问题。感音神经性听力损失是一种常见且使人虚弱的疾病，目前尚无全面的药物干预措施。导致听力损失的复杂和多样化的分子病理学目前限制了我们用小分子进行干预的能力。本综述重点介绍了外泌体在耳科学中的应用潜力。它检查了各种内耳疾病和听力损失，这些疾病可能可以使用外泌体（EXOs）来治疗。讨论了 EXOs 作为内耳相关疾病治疗载体的作用以及 EXOs 作为耳部相关疾病识别的生物标志物的作用。
