使用 DWI 中运动补偿梯度波形测量肝和胰腺表观扩散系数的精度。
Precision of liver and pancreas apparent diffusion coefficients using motion-compensated gradient waveforms in DWI.
机构信息
Department of Radiology, University of Wisconsin, Madison, WI, USA.
Department of Radiology, University of Wisconsin, Madison, WI, USA; Department of Medical Physics, University of Wisconsin, Madison, WI, USA.
出版信息
Magn Reson Imaging. 2024 Jul;110:161-169. doi: 10.1016/j.mri.2024.04.026. Epub 2024 Apr 18.
BACKGROUND
Diffusion weighted imaging (DWI) with optimized motion-compensated gradient waveforms reduces signal dropouts in the liver and pancreas caused by cardiovascular-associated motion, however its precision is unknown. We hypothesized that DWI with motion-compensated DW gradient waveforms would improve apparent diffusion coefficient (ADC)-repeatability and inter-reader reproducibility compared to conventional DWI in these organs.
METHODS
In this IRB-approved, prospective, single center study, subjects recruited between October 2019 and March 2020 were scanned twice on a 3 T scanner, with repositioning between test and retest. Each scan included two respiratory-triggered DWI series with comparable acquisition time: 1) conventional (monopolar) 2) motion- compensated diffusion gradients. Three readers measured ADC values. One-way ANOVA, Bland-Altman analysis were used for statistical analysis.
RESULTS
Eight healthy participants (4 male/4 female), with a mean age of 29 ± 4 years, underwent the liver and pancreas MRI protocol. Four patients with liver metastases (2 male/2 female) with a mean age of 58 ± 5 years underwent the liver MRI protocol. In healthy participants, motion-compensated DWI outperformed conventional DWI with mean repeatability coefficient of 0.14 × 10 (CI:0.12-0.17) vs. 0.31 × 10 (CI:0.27-0.37) mm/s for liver, and 0.11 × 10 (CI:0.08-0.15) vs. 0.34 × 10 (CI:0.27-0.49) mm/s for pancreas; and with mean reproducibility coefficient of 0.20 × 10 (CI:0.18-0.23) vs. 0.51 × 10 (CI:0.46-0.58) mm/s for liver, and 0.16 × 10 (CI:0.13-0.20) vs. 0.42 × 10 (CI:0.34-0.52) mm/s for pancreas. In patients, improved repeatability was observed for motion-compensated DWI in comparison to conventional with repeatability coefficient of 0.51 × 10 mm/s (CI:0.35-0.89) vs. 0.70 × 10 mm/s (CI:0.49-1.20).
CONCLUSION
Motion-compensated DWI enhances the precision of ADC measurements in the liver and pancreas compared to conventional DWI.
背景
扩散加权成像（DWI）采用优化的运动补偿梯度波形，可以减少与心血管相关运动引起的肝、胰信号丢失，但精度尚不清楚。我们假设，与传统 DWI 相比，运动补偿 DW 梯度波形的 DWI 可以提高肝、胰 ADC 的可重复性和读者间可重复性。
方法
本研究为经过机构审查委员会批准的前瞻性单中心研究，2019 年 10 月至 2020 年 3 月期间招募了受试者，在 3T 扫描仪上进行两次扫描，两次扫描之间需要重新定位。每个扫描都包括两个具有可比采集时间的呼吸触发的 DWI 序列：1）传统（单极）2）运动补偿扩散梯度。三位读者测量 ADC 值。采用单因素方差分析、Bland-Altman 分析进行统计分析。
结果
8 名健康参与者（4 名男性/4 名女性），平均年龄 29±4 岁，进行了肝、胰 MRI 方案检查。4 名患有肝转移瘤的患者（2 名男性/2 名女性），平均年龄 58±5 岁，进行了肝 MRI 方案检查。在健康参与者中，运动补偿 DWI 优于传统 DWI，肝脏的重复性系数平均值为 0.14×10（95%CI：0.12-0.17）vs.0.31×10（95%CI：0.27-0.37）mm/s，胰腺的重复性系数平均值为 0.11×10（95%CI：0.08-0.15）vs.0.34×10（95%CI：0.27-0.49）mm/s；肝脏的再现性系数平均值为 0.20×10（95%CI：0.18-0.23）vs.0.51×10（95%CI：0.46-0.58）mm/s，胰腺的再现性系数平均值为 0.16×10（95%CI：0.13-0.20）vs.0.42×10（95%CI：0.34-0.52）mm/s。在患者中，与传统 DWI 相比，运动补偿 DWI 的重复性有所提高，重复性系数为 0.51×10mm/s（95%CI：0.35-0.89）vs.0.70×10mm/s（95%CI：0.49-1.20）。
结论
与传统 DWI 相比，运动补偿 DWI 可提高肝、胰 ADC 测量的精度。
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