Pantaloni D, Hill T L, Carlier M F, Korn E D
Proc Natl Acad Sci U S A. 1985 Nov;82(21):7207-11. doi: 10.1073/pnas.82.21.7207.
A model for actin polymerization is proposed in which the rate of elongation of actin filaments depends on whether adenosine 5'-triphosphate or adenosine 5'-diphosphate is bound to the two terminal subunits of the filament. This model accounts quantitatively for the experimental data on the kinetics of filament elongation and explains the effect of ATP hydrolysis on actin polymerization.
提出了一种肌动蛋白聚合模型,其中肌动蛋白丝的伸长速率取决于三磷酸腺苷(ATP)或二磷酸腺苷(ADP)是否与丝的两个末端亚基结合。该模型定量地解释了关于丝伸长动力学的实验数据,并解释了ATP水解对肌动蛋白聚合的影响。