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副干酪乳杆菌 GMNL-143 牙膏对成人牙龈炎和口腔微生物群的影响：一项随机、双盲、交叉、安慰剂对照试验。

The impact of Lacticaseibacillus paracasei GMNL-143 toothpaste on gingivitis and oral microbiota in adults: a randomized, double-blind, crossover, placebo-controlled trial.

机构信息

Department of Dentistry, Kaohsiung Medical University Hospital, No.100, Shih-Chuan 1st Road, Sanmin Dist, Kaohsiung City, 807378, Taiwan.

Research and Development Department, GenMont Biotech Incorporation, Tainan City, 741014, Taiwan.

出版信息

BMC Oral Health. 2024 Apr 20;24(1):477. doi: 10.1186/s12903-024-04251-4.

DOI:10.1186/s12903-024-04251-4
PMID:38643116
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11031891/
Abstract

BACKGROUND

This study examines the oral health benefits of heat-killed Lacticaseibacillus paracasei GMNL-143, particularly its potential in oral microbiota alterations and gingivitis improvement.

METHODS

We assessed GMNL-143's in vitro interactions with oral pathogens and its ability to prevent pathogen adherence to gingival cells. A randomized, double-blind, crossover clinical trial was performed on gingivitis patients using GMNL-143 toothpaste or placebo for four weeks, followed by a crossover after a washout.

RESULTS

GMNL-143 showed coaggregation with oral pathogens in vitro, linked to its surface layer protein. In patients, GMNL-143 toothpaste lowered the gingival index and reduced Streptococcus mutans in crevicular fluid. A positive relationship was found between Aggregatibacter actinomycetemcomitans and gingival index changes, and a negative one between Campylobacter and gingival index changes in plaque.

CONCLUSION

GMNL-143 toothpaste may shift oral bacterial composition towards a healthier state, suggesting its potential in managing mild to moderate gingivitis.

TRIAL REGISTRATION

ID NCT04190485 ( https://clinicaltrials.gov/ ); 09/12/2019, retrospective registration.

摘要

背景

本研究考察了热灭活副干酪乳杆菌 GMNL-143 的口腔健康益处，特别是其在口腔微生物群改变和牙龈炎改善方面的潜力。

方法

我们评估了 GMNL-143 与口腔病原体的体外相互作用及其防止病原体附着在牙龈细胞上的能力。对牙龈炎患者进行了一项随机、双盲、交叉临床试验，使用 GMNL-143 牙膏或安慰剂治疗四周，然后在洗脱期后进行交叉。

结果

GMNL-143 在体外与口腔病原体发生共聚集，这与其表面层蛋白有关。在患者中，GMNL-143 牙膏降低了牙龈指数并减少了龈沟液中的变形链球菌。在菌斑中，牙龈指数变化与放线共生放线杆菌之间存在正相关，与弯曲菌之间存在负相关。

结论

GMNL-143 牙膏可能会使口腔细菌组成向更健康的状态转变，这表明其在治疗轻度至中度牙龈炎方面具有潜力。

试验注册

ID NCT04190485（https://clinicaltrials.gov/）；2019 年 9 月 12 日，回顾性注册。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3423/11031891/5117ba8e8dfc/12903_2024_4251_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3423/11031891/d16df6739842/12903_2024_4251_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3423/11031891/c6c94a37d4bd/12903_2024_4251_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3423/11031891/df31918df5a9/12903_2024_4251_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3423/11031891/7c875cd80d66/12903_2024_4251_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3423/11031891/5117ba8e8dfc/12903_2024_4251_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3423/11031891/d16df6739842/12903_2024_4251_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3423/11031891/c6c94a37d4bd/12903_2024_4251_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3423/11031891/df31918df5a9/12903_2024_4251_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3423/11031891/7c875cd80d66/12903_2024_4251_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3423/11031891/5117ba8e8dfc/12903_2024_4251_Fig5_HTML.jpg

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