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2
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Prevention of aspirin-induced fecal blood loss with oral prostaglandin E2: dose-response studies in man.口服前列腺素E2预防阿司匹林引起的粪便失血：人体剂量反应研究
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吸烟会降低人体胃腔内前列腺素E2的水平。

Cigarette smoking reduces human gastric luminal prostaglandin E2.

作者信息

McCready D R, Clark L, Cohen M M

出版信息

Gut. 1985 Nov;26(11):1192-6. doi: 10.1136/gut.26.11.1192.

DOI:10.1136/gut.26.11.1192
PMID:3864718
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1432902/
Abstract

The effect of smoking three cigarettes on the release of prostaglandin E2 (PGE2) by the gastric mucosa was studied in seven healthy smokers. Smoking caused the expected increases in pulse rate, blood pressure, plasma glucose, and carboxyhaemoglobin. In addition, smoking resulted in a significant (p less than 0.05) reduction in the volume of pentagastrin stimulated gastric juice from 76.1 +/- 4.4 to 54.1 +/- 4.6 ml/15 min and PGE2 output from 22.8 +/- 4.9 to 12.2 +/- 3.8 ng/15 min but did not alter acid output. It is concluded that smoking reduces the amount of PGE2 in the gastric lumen and that this may explain why it is a risk factor for peptic ulcer.

摘要

对7名健康吸烟者进行了研究，以探讨吸3支香烟对胃黏膜释放前列腺素E2（PGE2）的影响。吸烟导致脉搏率、血压、血糖和羧基血红蛋白如预期般升高。此外，吸烟还导致五肽胃泌素刺激的胃液量从76.1±4.4显著减少至54.1±4.6毫升/15分钟（p<0.05），PGE2产量从22.8±4.9降至12.2±3.8纳克/15分钟，但未改变胃酸分泌量。研究得出结论，吸烟会减少胃腔内PGE2的量，这可能解释了吸烟为何是消化性溃疡的一个危险因素。