Tang Qian, Song Dingguo, Zhang Kali, Mao Wenhao, Zhao Xianghua, Du Ding, Ling Fei, Zhong Weihui
Department of Chemistry, State Key Laboratory of Natural Medicines, China Pharmaceutical University Nan Jing 210009 P. R. China
Zhejiang Center for Drug &Cosmetic Evaluation Hangzhou 310012 P. R. China.
RSC Adv. 2024 Apr 22;14(19):12978-12982. doi: 10.1039/d4ra00817k.
3d-Metal catalyzed borrowing hydrogen (BH) reactions represent powerful and environmentally friendly approaches for the direct coupling of alcohols with nitriles to assemble various important branched nitriles. The development of simple and efficient ligands is a crucial issue in this field. In this study, we designed a series of readily available ,-bidentate ligands that demonstrated good efficiency in the Mn-catalyzed BH reaction of alcohols and nitrile derivatives, yielding the targeted nitriles in moderate to good yields. Remarkably, the mildness and practicality of this protocol were further demonstrated by the successful synthesis of anipamil a two-cascade borrowing hydrogen procedure.
3D金属催化的借氢（BH）反应是醇与腈直接偶联以组装各种重要支链腈的强大且环境友好的方法。开发简单有效的配体是该领域的关键问题。在本研究中，我们设计了一系列易于获得的α，β-双齿配体，这些配体在锰催化的醇与腈衍生物的BH反应中表现出良好的效率，以中等至良好的产率得到目标腈。值得注意的是，通过成功合成阿尼帕米——一种双级联借氢过程，进一步证明了该方法的温和性和实用性。
