Sobral School of Medicine, Federal University of Ceará, Avenida Comandante Maurocélio Rocha Ponte, 100 - CEP 62,042-280, Sobral, CE, Brazil.
BMC Nephrol. 2013 Dec 14;14:275. doi: 10.1186/1471-2369-14-275.
Dyspepsia is common among end-stage renal disease (ESRD) patients and its association with delayed gastric emptying is not well established. We assessed the association of dyspepsia with gastric emptying time in ESRD patients undergoing hemodialysis (HD).
Dyspepsia was assessed through the Porto Alegre Dyspeptic Symptoms Questionnaire (PADYQ). PADYQ's scores ≥ 6 classified participants as dyspeptic. The octanoic acid breath test using ¹³carbon was employed to assess the gastric emptying time. Based on the test, time in minutes to metabolize the first half of the ¹³carbon in the test meal (t1/2) was calculated. Association of dyspepsia with gastric emptying time was tested by the correlation between PADYQ scores and t1/2, and also by comparing t1/2 between dyspeptics and non-dyspeptics.
There were 34 (68.0%) dyspeptic patients. Dyspepsia score was positively correlated with t1/2 (r = 0.366; p = 0.009). Dyspeptics had longer t1/2 compared to non-dyspeptics, respectively, 238.0 ± 92.9 versus 185.5 ± 45.5 minutes (p = 0.042).
Delayed gastric emptying was associated with dyspepsia. Prokinetic medications could have a role in preventing or relieving dyspeptic symptoms among HD patients. Future research in larger samples is necessary to confirm this association.
消化不良在终末期肾病（ESRD）患者中很常见，但其与胃排空延迟的关系尚未得到充分证实。我们评估了在接受血液透析（HD）的 ESRD 患者中，消化不良与胃排空时间的关系。
通过 Porto Alegre 消化不良症状问卷（PADYQ）评估消化不良。PADYQ 的得分≥6 分将参与者归类为消化不良。使用¹³碳辛酸呼气试验评估胃排空时间。根据该试验，计算出测试餐中¹³碳的前半部分代谢所需的时间（t1/2）。通过 PADYQ 评分与 t1/2 之间的相关性以及通过比较消化不良者和非消化不良者之间的 t1/2 来检验消化不良与胃排空时间的关系。
有 34 名（68.0%）患者出现消化不良。消化不良评分与 t1/2 呈正相关（r=0.366；p=0.009）。消化不良者的 t1/2 分别长于非消化不良者，分别为 238.0±92.9 分钟和 185.5±45.5 分钟（p=0.042）。
胃排空延迟与消化不良有关。促动力药物可能在预防或缓解 HD 患者的消化不良症状方面发挥作用。需要在更大的样本中进行进一步研究以证实这种关联。
