Ribeiro Laryssa Freitas, Nespolo Natália Maramarque, Rossi Gabriel Augusto Marques, Fairbrother John Morris
Mário Palmério University Center (UniFucamp), Av. Brasil Oeste, s/n, Jardim Zenith, Monte Carmelo 38500-000, Minas Gerais State, Brazil.
Federal University of São Carlos (UFSCar), Rod. Washington Luís, s/n-Monjolinho, São Carlos 13565-905, São Paulo State, Brazil.
Pathogens. 2024 Apr 22;13(4):346. doi: 10.3390/pathogens13040346.
Antimicrobials serve as crucial treatments in both veterinary and human medicine, aiding in the control and prevention of infectious diseases. However, their misuse or overuse has led to the emergence of antimicrobial resistance, posing a significant threat to public health. This review focuses on extended-spectrum beta-lactamase (ESBL)-producing in animals and their associated food products, which contribute to the proliferation of antimicrobial-resistant strains. Recent research has highlighted the presence of ESBL-producing in animals and animal-derived foods, with some studies indicating genetic similarities between these isolates and those found in human infections. This underscores the urgent need to address antimicrobial resistance as a pressing public health issue. More comprehensive studies are required to understand the evolving landscape of ESBLs and to develop strategic public health policies grounded in the One Health approach, aiming to control and mitigate their prevalence effectively.
抗菌药物在兽医学和人类医学中都是至关重要的治疗手段，有助于控制和预防传染病。然而，它们的滥用或过度使用导致了抗菌药物耐药性的出现，对公众健康构成了重大威胁。本综述聚焦于动物及其相关食品中产生超广谱β-内酰胺酶（ESBL）的情况，这会促使抗菌药物耐药菌株的扩散。最近的研究突出了动物和动物源性食品中产生ESBL的情况，一些研究表明这些分离株与人类感染中发现的分离株存在基因相似性。这凸显了将抗菌药物耐药性作为一个紧迫的公共卫生问题加以解决的迫切需求。需要进行更全面的研究，以了解ESBLs不断变化的情况，并制定基于“同一健康”方法的战略公共卫生政策，旨在有效控制和减轻它们的流行。
