Department of Preventive and Restorative Dentistry, School of Dentistry, Araçatuba, Sao Paulo State University (UNESP), SP, Brazil.
University Medical Center Göttingen, Department of Preventive Dentistry, Periodontology and Cariology, Göttingen, Germany.
Arch Oral Biol. 2024 Jul;163:105973. doi: 10.1016/j.archoralbio.2024.105973. Epub 2024 Apr 15.
The study assessed the effect of low-fluoride gels supplemented with micrometric or nano-sized sodium trimetaphosphate (TMP) on dentin erosive wear in vitro.
Bovine dentin blocks (n = 154) were selected by surface microhardness and randomly allocated into seven groups (n = 22/group), according to the gels: Placebo; 4500 ppm F (4500F); 9000 ppm F (9000F); 5% TMP microparticulate plus 4500F (5TMPm+4500F); 2.5% TMP nanoparticulate plus 4500 F (2.5TMPn+4500F); 5% TMP nanoparticulate plus 4500F (5TMPn+4500F); and 12,300 ppm F acid gel (APF). All blocks were treated only once for 60 s and cyclically eroded (ERO, citric acid, 4 × 90 s/day) or eroded and brushed (4 × 15 s/day, five strokes/s, ERO+ABR) over five days (each subgroup n = 11). Dentin wear and integrated hardness loss in depth (ΔKHN) were determined, and the data were submitted to two-way ANOVA, followed by Tukey's test, and Spearman's correlation (p < 0.05).
For ERO, all gels containing 4500F supplemented with TMP significantly reduced dentin wear compared with their counterpart without TMP, reaching values similar to 9000F. For ERO+ABR, 5TMPn+ 4500F gel led to significantly lower wear than all its counterparts, reaching values similar to 9000F and APF. As for ΔKHN, all gels containing TMP promoted superior protective effects compared with 4500F, reaching values similar to 9000F and APF under both challenges. A positive correlation between dentin wear and mineral content in depth was verified.
Gels containing 4500F supplemented with TMP significantly reduced dentin erosive wear compared with pure 4500F, with additional benefit from the use of nanoparticles.
本研究评估了添加纳米或微米级三聚磷酸钠（TMP）的低氟凝胶对体外牙本质腐蚀性磨损的影响。
选择牛牙本质块（n=154），根据凝胶进行表面显微硬度测试，然后随机分为 7 组（n=22/组），分别为：安慰剂；4500ppm F（4500F）；9000ppm F（9000F）；5%TMP 微粒体加 4500F（5TMPm+4500F）；2.5%TMP 纳米体加 4500F（2.5TMPn+4500F）；5%TMP 纳米体加 4500F（5TMPn+4500F）；和 12300ppm F 酸凝胶（APF）。所有牙本质块仅接受一次 60s 的处理，然后进行循环侵蚀（ERO，柠檬酸，每天 4×90s）或侵蚀和刷洗（每天 4×15s，5 次/秒，ERO+ABR），共 5 天（每组 n=11）。测量牙本质磨损和深度综合硬度损失（ΔKHN），并对数据进行双因素方差分析，然后进行 Tukey 检验和 Spearman 相关性分析（p<0.05）。
对于 ERO，所有添加 TMP 的 4500F 凝胶与不含 TMP 的相应凝胶相比，牙本质磨损显著减少，达到与 9000F 相似的水平。对于 ERO+ABR，5TMPn+4500F 凝胶的磨损显著低于所有其他对照凝胶，达到与 9000F 和 APF 相似的水平。对于 ΔKHN，所有含有 TMP 的凝胶与单独的 4500F 凝胶相比，都具有更好的保护作用，在两种挑战下，都达到与 9000F 和 APF 相似的水平。验证了牙本质磨损与深度矿物含量之间存在正相关关系。
与纯 4500F 相比，添加 TMP 的 4500F 凝胶显著减少牙本质腐蚀性磨损，使用纳米颗粒还有额外的益处。
