Wu Yongzhen, Zhou Taoxiu, Yang Shengmei, Yin Baofa, Wu Ruiyong, Wei Wanhong
College of Bioscience and Biotechnology, Yangzhou University, Yangzhou 225009, China.
Microorganisms. 2024 Mar 28;12(4):671. doi: 10.3390/microorganisms12040671.
Rodents, including the striped field mouse (), play vital roles in ecosystem functioning, with their gut microbiota contributing significantly to various ecological processes. Here, we investigated the structure and function of 94 wild individuals from 7 geographic populations (45°57' N, 126°48' E; 45°87' N, 126°37' E; 45°50' N, 125°31' E; 45°59' N, 124°37' E; 46°01' N, 124°88' E; 46°01' N, 124°88' E; 46°01' N, 124°88' E), revealing two distinct enterotypes (Type1 and Type2) for the first time. Each enterotype showed unique microbial diversity, functions, and assembly processes. Firmicutes and Bacteroidetes dominated, with a significant presence of and Functional analysis highlighted metabolic differences, with Type1 emphasizing nutrient processing and Type2 showing higher energy production capacity. The analysis of the neutral model and the null model revealed a mix of stochastic (drift and homogenizing dispersal) and deterministic processes (homogenous selection) that shape the assembly of the microbiota, with subtle differences in the assembly processes between the two enterotypes. Correlation analysis showed that elevation and BMI were associated with the phylogenetic turnover of microbial communities, suggesting that variations in these factors may influence the composition and diversity of the gut microbiota in . Our study sheds light on gut microbial dynamics in wild populations, highlighting the importance of considering ecological and physiological factors in understanding host-microbiota interactions.
啮齿动物，包括条纹田鼠（ ），在生态系统功能中发挥着至关重要的作用，其肠道微生物群对各种生态过程有重大贡献。在此，我们调查了来自7个地理种群（北纬45°57'，东经126°48'；北纬45°87'，东经126°37'；北纬45°50'，东经125°31'；北纬45°59'，东经124°37'；北纬46°01'，东经124°88'；北纬46°01'，东经124°88'；北纬46°01'，东经124°88'）的94只野生个体的结构和功能，首次揭示了两种不同的肠型（1型和2型）。每种肠型都表现出独特的微生物多样性、功能和组装过程。厚壁菌门和拟杆菌门占主导地位， 和 大量存在。功能分析突出了代谢差异，1型强调营养物质处理，2型显示出更高的能量生产能力。中性模型和零模型分析揭示了塑造微生物群组装的随机过程（漂移和同质化扩散）和确定性过程（同质选择）的混合，两种肠型在组装过程中存在细微差异。相关性分析表明，海拔和体重指数与微生物群落的系统发育周转率相关，表明这些因素的变化可能影响条纹田鼠肠道微生物群的组成和多样性。我们的研究揭示了野生条纹田鼠种群的肠道微生物动态，强调了在理解宿主 - 微生物群相互作用时考虑生态和生理因素的重要性。
