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从泡菜中分离出的ASC-1通过降解大鼠体内尿酸来改善高尿酸血症。

ASC-1 Isolated from Pickled Cabbage Ameliorates Hyperuricemia by Degrading Uric Acid in Rats.

作者信息

Zhu Wenjuan, Bi Siyuan, Fang Zhijia, Iddrisu Lukman, Deng Qi, Sun Lijun, Gooneratne Ravi

机构信息

Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Provincial Engineering Technology, Research Center of Marine Food, Key Laboratory of Advanced Processing of Aquatic Products of Guangdong Higher Education Institution, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China.

Department of Wine, Food and Molecular Biosciences, Lincoln University, Lincoln 7647, Canterbury, New Zealand.

出版信息

Microorganisms. 2024 Apr 20;12(4):832. doi: 10.3390/microorganisms12040832.

DOI:10.3390/microorganisms12040832
PMID:38674776
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11052324/
Abstract

Pickled cabbage, a traditional fermented food rich in functional microorganisms, can effectively control hyperuricemia and gout. In this study, a ASC-1 strain with strong uric acid (UA) degradation ability was isolated from pickled cabbage. After oral administration for 15 days, ASC-1 was stably colonized in the rats in this study. ASC-1 significantly reduced UA levels (67.24%) in hyperuricemic rats. Additionally, ASC-1 alleviated hyperuricemia-related inflammatory response, oxidative stress, and blood urea nitrogen. Intestinal microbial diversity results showed that ASC-1 restored intestinal injury and gut flora dysbiosis caused by hyperuricemia. These findings suggest that ASC-1 may be used as a therapeutic adjuvant for the treatment of hyperuricemia.

摘要

泡菜是一种富含功能性微生物的传统发酵食品，能够有效控制高尿酸血症和痛风。在本研究中，从泡菜中分离出一株具有强大尿酸（UA）降解能力的ASC-1菌株。在本研究中，口服给药15天后，ASC-1在大鼠体内稳定定植。ASC-1显著降低了高尿酸血症大鼠的尿酸水平（67.24%）。此外，ASC-1减轻了与高尿酸血症相关的炎症反应、氧化应激和血尿素氮。肠道微生物多样性结果表明，ASC-1修复了由高尿酸血症引起的肠道损伤和肠道菌群失调。这些发现表明，ASC-1可作为治疗高尿酸血症的辅助治疗剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f755/11052324/2e0400a96c67/microorganisms-12-00832-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f755/11052324/484d8c43c832/microorganisms-12-00832-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f755/11052324/e02f6d4a897e/microorganisms-12-00832-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f755/11052324/51ba70dfc96d/microorganisms-12-00832-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f755/11052324/18b5f7ab40f9/microorganisms-12-00832-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f755/11052324/2e0400a96c67/microorganisms-12-00832-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f755/11052324/484d8c43c832/microorganisms-12-00832-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f755/11052324/e02f6d4a897e/microorganisms-12-00832-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f755/11052324/51ba70dfc96d/microorganisms-12-00832-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f755/11052324/18b5f7ab40f9/microorganisms-12-00832-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f755/11052324/2e0400a96c67/microorganisms-12-00832-g005.jpg

相似文献

[1]
ASC-1 Isolated from Pickled Cabbage Ameliorates Hyperuricemia by Degrading Uric Acid in Rats.

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[7]
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[10]
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引用本文的文献

[1]
Novel Potential Probiotics from Chinese Baijiu Fermentation Grains: Dual Action of LTJ1/LTJ48 in Uric Acid Reduction and Gut Microbiota Restoration for Hyperuricemia Therapy in Mice.

Nutrients. 2025-6-24

[2]
Dietary intake of live microbes mitigates the mortality risk associated with sedentary behavior in US hypertensive individuals.

Sci Rep. 2025-5-12

本文引用的文献

[1]
Commentary: Gut microbiota reduce the risk of hyperuricemia and gout in the human body.

Acta Pharm Sin B. 2024-1

[2]
Assessment of the temporal trend and daily profiles of the dietary purine intake among Chinese residents during 2014 to 2021.

Front Nutr. 2023-11-9

[3]
Agents for the Treatment of Gout: Current Advances and Future Perspectives.

J Med Chem. 2023-11-9

[4]
Probiotic-fermented tomato alleviates high-fat diet-induced obesity in mice: Insights from microbiome and metabolomics.

Food Chem. 2024-3-15

[5]
Causal Relationship between Gut Microbiota and Gout: A Two-Sample Mendelian Randomization Study.

Nutrients. 2023-10-5

[6]
Biodegradation of Uric Acid by -YC02.

Microorganisms. 2023-8-2

[7]
An Updated Review For Hyperuricemia and Gout Management; Special Focus on the Available Drug Delivery Systems and Clinical Trials.

Curr Med Chem. 2024

[8]
Tumor-targeting engineered probiotic Escherichia coli Nissle 1917 inhibits colorectal tumorigenesis and modulates gut microbiota homeostasis in mice.

Life Sci. 2023-7-1

[9]
F40-4 ameliorates hyperuricemia by modulating the gut microbiota and alleviating inflammation in mice.

Food Funct. 2023-4-3

[10]
Novel urate transporter 1 (URAT1) inhibitors: a review of recent patent literature (2020-present).

Expert Opin Ther Pat. 2022-12

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