Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran; Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Cardiac Primary Prevention Research Center (CPPRC), Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
J Ethnopharmacol. 2024 Aug 10;330:118243. doi: 10.1016/j.jep.2024.118243. Epub 2024 Apr 25.
Pomegranate 'Punica granatum' offers multiple health benefits, including managing hypertension, dyslipidemia, hyperglycemia, insulin resistance, and enhancing wound healing and infection resistance, thanks to its potent antioxidant and anti-inflammatory properties. It has been symbolized by life, health, femininity, fecundity, and spirituality.
Although laboratory and animal studies have been conducted on the healing effects of pomegranate, there needs to be a comprehensive review on its anti-oxidative and anti-inflammatory effects in chronic disorders. We aim to provide a comprehensive review of these effects based on in-vitro, in-vivo, and clinical studies conducted in managing various disorders.
A comprehensive search of in-vitro, in-vivo, and clinical findings of pomegranate and its derivatives focusing on the highly qualified original studies and systematic reviews are carried out in valid international web databases, including Web of Science, PubMed, Scopus, and Cochrane Library.
Relevant studies have demonstrated that pomegranate and its derivatives can modulate the expression and activity of several genes, enzymes, and receptors through influencing oxidative stress and inflammation pathways. Different parts of pomegranate; roots, bark, blossoms, fruits, and leaves contain various bioactive compounds, such as polyphenols, flavonoids, anthocyanins, and ellagitannins, that have preventive and therapeutic effects against many disorders such as cardiovascular diseases, diabetes, neurological diseases, and cancers without any serious adverse effects.
Most recent scientific evidence indicates that all parts of the pomegranate can be helpful in treating a wide range of chronic disorders due to its anti-oxidative and anti-inflammatory activities. Since the safety of pomegranate fruit, juice, and extracts is established, further investigations can be designed by targeting its active antioxidant and anti-inflammatory constituents to discover new drugs.
石榴（Punica granatum）具有多种健康益处，包括管理高血压、血脂异常、高血糖、胰岛素抵抗，并通过其强大的抗氧化和抗炎特性增强伤口愈合和抗感染能力。它被象征着生命、健康、女性气质、生育能力和精神性。
尽管已经对石榴的愈合作用进行了实验室和动物研究，但仍需要对其在慢性疾病中的抗氧化和抗炎作用进行全面综述。我们旨在根据在管理各种疾病方面进行的体外、体内和临床研究，提供对这些作用的全面综述。
在有效的国际网络数据库中，全面搜索石榴及其衍生物的体外、体内和临床发现，重点关注高质量的原始研究和系统评价。这些数据库包括 Web of Science、PubMed、Scopus 和 Cochrane Library。
相关研究表明，石榴及其衍生物可以通过影响氧化应激和炎症途径来调节几种基因、酶和受体的表达和活性。石榴的不同部位；根、皮、花、果实和叶含有各种生物活性化合物，如多酚、类黄酮、花青素和鞣花单宁，对许多疾病（如心血管疾病、糖尿病、神经疾病和癌症）具有预防和治疗作用，而没有任何严重的不良影响。
最新的科学证据表明，由于其抗氧化和抗炎活性，石榴的所有部位都有助于治疗广泛的慢性疾病。由于石榴果实、果汁和提取物的安全性已经确立，因此可以设计进一步的调查，针对其活性抗氧化和抗炎成分来发现新的药物。
