A genetic optimisation and iterative reconstruction framework for sparse multi-dimensional diffusion-relaxation correlation MRI.

Multi-dimensional diffusion-relaxation correlation (DRC) magnetic resonance imaging (MRI) techniques have recently been developed to investigate tissue microstructures. Sub-voxel tissue heterogeneity is resolved from the local correlation distributions of relaxation time and molecular diffusivity. However, the implementation of these techniques considerably increases the total acquisition time, and simply reducing the scan time may be at the expense of detailed structural resolution. To overcome these limitations, an optimised framework was proposed for acquiring microstructural maps of the human brain on a clinically feasible timescale. First, the acquisition parameters of the multi-dimensional DRC MRI method were sparsely optimised using a genetic algorithm with a fitness function according to the spectral resolution of the correlation map, hardware requirements, and total scan time. Next, the acquired DRC MRI data were processed using a proposed numerical algorithm based on the dynamic inverse Laplace transform (ILT). Prior knowledge from one-dimensional data was then utilised in the iterative procedure to improve the spectral resolution. Finally, the proposed framework was validated using Monte Carlo simulations and experimental data acquired from healthy participants on an MRI scanner. The results demonstrated that the suggested approach is feasible for offering high-resolution DRC maps that correspond to distinct microstructures with a limited amount of optimised acquisition data from two-dimensional DRC sampling space. By significantly reducing scan time while retaining structural resolution, this approach may enable multi-dimensional DRC MRI to be more widely used for quantitative evaluation in biological and medical settings.