Division of Gastroenterology and Digestive Endoscopy, Department of Medical Sciences, Central Hospital - Azienda Ospedaliera, Taranto 74123, Italy.
World J Gastroenterol. 2024 Apr 14;30(14):1963-1967. doi: 10.3748/wjg.v30.i14.1963.
Digestion and intestinal absorption allow the body to sustain itself and are the emblematic functions of the bowel. On the flip side, functions also arise from its role as an interface with the environment. Indeed, the gut houses microorganisms, collectively known as the gut microbiota, which interact with the host, and is the site of complex immune activities. Its role in human pathology is complex and scientific evidence is progressively elucidating the functions of the gut, especially regarding the pathogenesis of chronic intestinal diseases and inflammatory conditions affecting various organs and systems. This editorial aims to highlight and relate the factors involved in the pathogenesis of intestinal and systemic inflammation.
消化和肠道吸收使身体能够维持自身的正常运转，是肠道的标志性功能。另一方面，肠道作为与环境相互作用的界面，也产生了一些功能。事实上，肠道内居住着微生物，这些微生物统称为肠道微生物群，它们与宿主相互作用，并参与复杂的免疫活动。它在人类病理学中的作用是复杂的，科学证据正在逐步阐明肠道的功能，特别是关于影响各种器官和系统的慢性肠道疾病和炎症性疾病的发病机制。本社论旨在强调并阐述肠道和系统性炎症发病机制中的相关因素。
