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基于高效液相色谱的碳水化合物自动化合成与纯化

HPLC-Based Automated Synthesis and Purification of Carbohydrates.

机构信息

Department of Chemistry, Saint Louis University, 3501Laclede Ave, St. Louis, Missouri, 63103, USA.

Department of Chemistry, University of Milan, Via Golgi 19, Milan, 20133, Italy.

出版信息

Chemistry. 2024 Aug 1;30(43):e202401214. doi: 10.1002/chem.202401214. Epub 2024 May 29.

Abstract

Reported herein is a new HPLC-based automated synthesizer (HPLC-A) capable of a temperature-controlled synthesis and purification of carbohydrates. The developed platform allows to perform various protecting group manipulations as well as the synthesis of O- and N-glycosides. A fully automated synthesis and purification was showcased in application to different carbohydrate derivatives including glycosides, oligosaccharides, glycopeptides, glycolipids, and nucleosides.

摘要

本文报道了一种基于高效液相色谱的新型自动化合成仪(HPLC-A),该合成仪能够实现碳水化合物的温控合成和纯化。所开发的平台允许进行各种保护基操作以及 O-和 N-糖苷的合成。通过对包括糖苷、寡糖、糖肽、糖脂和核苷在内的不同碳水化合物衍生物的应用,展示了全自动合成和纯化的过程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8375/11586687/79308606ae18/nihms-2033935-f0001.jpg

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