Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, 48201, USA.
Department of Biochemistry, Microbiology, and Immunology, Wayne State University School of Medicine, Detroit, MI, 48201, USA.
Sci Rep. 2024 Apr 30;14(1):9936. doi: 10.1038/s41598-024-59998-1.
Mitochondria, the powerhouse and the vital signaling hub of the cell, participate in a variety of biological processes, such as apoptosis, redox responses, cell senescence, autophagy, and iron homeostasis. Mitochondria form a mostly tubular network, made up of an outer and a cristeae-forming inner membrane. The network undergoes dynamic fusion and fission that change its morphological structure according to the functional needs. Approximately 1500 mitochondrial proteins encoded by nuclear genome plus over 10 proteins encoded by mitochondrial DNA are folded and assembled in the mitochondria under a high-fidelity control system. These proteins are involved in oxidative phosphorylation, metabolism, network and cristae dynamics, mitophagy, import machinery, ion channels, and mitochondrial DNA maintenance. This Collection gathers original research that advances our understanding of the monitoring techniques and pathophysiological significance of mitochondrial dynamics in health and disease.
线粒体是细胞的动力和重要信号中心，参与多种生物学过程，如细胞凋亡、氧化还原反应、细胞衰老、自噬和铁稳态。线粒体形成一个主要由管状网络组成的结构，由外膜和形成嵴的内膜组成。该网络经历动态融合和裂变，根据功能需求改变其形态结构。大约 1500 种由核基因组编码的线粒体蛋白加上 10 多种由线粒体 DNA 编码的蛋白在线粒体中在高保真控制系统下折叠和组装。这些蛋白参与氧化磷酸化、代谢、网络和嵴动力学、线粒体自噬、导入机制、离子通道和线粒体 DNA 维持。本合集汇集了原始研究，增进了我们对线粒体动力学在健康和疾病中的监测技术和病理生理意义的理解。
