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石香薷嫩枝化学成分的抗病毒和抗炎活性

Antiviral and anti-inflammatory activities of chemical constituents from twigs of Mosla chinensis Maxim.

作者信息

Feng Shi-Yan, Jiang Na, Yang Jia-Ying, Yang Lin-Yao, Du Jiang-Chao, Chen Xuan-Qin, Liu Dan, Li Rong-Tao, Zhong Jin-Dong

机构信息

Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, Yunnan, People's Republic of China.

出版信息

Nat Prod Bioprospect. 2024 May 1;14(1):26. doi: 10.1007/s13659-024-00448-w.

DOI:10.1007/s13659-024-00448-w
PMID:38691189
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11063020/
Abstract

Seven undescribed compounds, including three flavones (1-3), one phenylpropanoid (19), three monoaromatic hydrocarbons (27-29), were isolated from the twigs of Mosla chinensis Maxim together with twenty-eight known compounds. The structures were characterized by HRESIMS, 1D and 2D NMR, and ECD spectroscopic techniques. Compound 20 displayed the most significant activity against A/WSN/33/2009 (H1N1) virus (IC = 20.47 μM) compared to the positive control oseltamivir (IC = 6.85 µM). Further research on the anti-influenza mechanism showed that compound 20 could bind to H1N1 virus surface antigen HA1 and inhibit the early attachment stage of the virus. Furthermore, compounds 9, 22, 23, and 25 displayed moderate inhibitory effects on the NO expression in LPS inducing Raw 264.7 cells with IC values of 22.78, 20.47, 27.66, and 30.14 µM, respectively.

摘要

从石香薷嫩枝中分离得到7个未描述的化合物，包括3个黄酮类化合物（1-3）、1个苯丙素类化合物（19）、3个单芳香烃类化合物（27-29），以及28个已知化合物。通过高分辨电喷雾电离质谱（HRESIMS）、一维和二维核磁共振（1D和2D NMR）以及电子圆二色谱（ECD）光谱技术对其结构进行了表征。与阳性对照药奥司他韦（IC = 6.85 μM）相比，化合物20对A/WSN/33/2009（H1N1）病毒表现出最显著的活性（IC = 20.47 μM）。对其抗流感机制的进一步研究表明，化合物20可与H1N1病毒表面抗原HA1结合，并抑制病毒的早期附着阶段。此外，化合物9、22、23和25对脂多糖诱导的Raw 264.7细胞中NO的表达显示出中等程度的抑制作用，IC值分别为22.78、20.47、27.66和30.14 μM。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1802/11063020/4f63bfc54136/13659_2024_448_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1802/11063020/21525a68cf42/13659_2024_448_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1802/11063020/0787911f1d4a/13659_2024_448_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1802/11063020/78814c869bbb/13659_2024_448_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1802/11063020/38e0dfdd8dd2/13659_2024_448_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1802/11063020/02b6da361f1c/13659_2024_448_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1802/11063020/4f63bfc54136/13659_2024_448_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1802/11063020/21525a68cf42/13659_2024_448_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1802/11063020/a40edf287eac/13659_2024_448_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1802/11063020/ce76674647a6/13659_2024_448_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1802/11063020/0787911f1d4a/13659_2024_448_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1802/11063020/78814c869bbb/13659_2024_448_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1802/11063020/38e0dfdd8dd2/13659_2024_448_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1802/11063020/02b6da361f1c/13659_2024_448_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1802/11063020/4f63bfc54136/13659_2024_448_Fig8_HTML.jpg

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