Yang Mengyun, Ji Chendong, Yin Meizhen
State Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, China.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2024 May-Jun;16(3):e1960. doi: 10.1002/wnan.1960.
Photothermal therapy (PTT) represents a groundbreaking approach to targeted disease treatment by harnessing the conversion of light into heat. The efficacy of PTT heavily relies on the capabilities of photothermal agents (PTAs). Among PTAs, those based on organic dyes exhibit notable characteristics such as adjustable light absorption wavelengths, high extinction coefficients, and high compatibility in biological systems. However, a challenge associated with organic dye-based PTAs lies in their efficiency in converting light into heat while maintaining stability. Manipulating dye aggregation is a key aspect in modulating non-radiative decay pathways, aiming to augment heat generation. This review delves into various strategies aimed at improving photothermal performance through constructing aggregation. These strategies including protecting dyes from photodegradation, inhibiting non-photothermal pathways, maintaining space within molecular aggregates, and introducing intermolecular photophysical processes. Overall, this review highlights the precision-driven assembly of organic dyes as a promising frontier in enhancing PTT-related applications. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Diagnostic Tools > In Vivo Nanodiagnostics and Imaging.
光热疗法（PTT）是一种通过利用光向热的转化来进行靶向疾病治疗的开创性方法。PTT的疗效在很大程度上依赖于光热剂（PTA）的性能。在PTA中，基于有机染料的PTA具有显著特性，如可调节的光吸收波长、高消光系数以及在生物系统中的高兼容性。然而，基于有机染料的PTA存在一个挑战，即它们在保持稳定性的同时将光转化为热的效率。控制染料聚集是调节非辐射衰变途径的一个关键方面，旨在增加热量产生。本综述深入探讨了通过构建聚集来提高光热性能的各种策略。这些策略包括保护染料免受光降解、抑制非光热途径、保持分子聚集体内的空间以及引入分子间光物理过程。总体而言，本综述强调了有机染料的精确驱动组装作为增强PTT相关应用的一个有前景的前沿领域。本文分类如下：治疗方法与药物发现>新兴技术；治疗方法与药物发现>肿瘤疾病的纳米医学；诊断工具>体内纳米诊断与成像。
