Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Chuncheon Sacred Heart Hospital, Hallym University Medical Center, Chuncheon-si, Gangwon-do, 24253, Republic of Korea.
AI Product Team, Gmarket, Seoul, Republic of Korea.
Sci Rep. 2024 May 2;14(1):10074. doi: 10.1038/s41598-024-59643-x.
We aimed to examine the impact of COVID-19 non-pharmaceutical interventions (NPIs) on the relationship between air pollutants and hospital admissions for respiratory and non-respiratory diseases in six metropolitan cities in South Korea. This study compared the associations between particulate matter (PM and PM) and hospital admission for respiratory and non-respiratory diseases before (2016-2019) and during (2020) the implementation of COVID-19 NPIs by using distributed lag non-linear models. In the Pre-COVID-19 period, the association between PM and admission risk for asthma and COPD showed an inverted U-shaped pattern. For PM, S-shaped and inverted U-shaped changes were observed in asthma and COPD, respectively. Extremely high and low levels of PM and extremely low levels of PM significantly decreased the risk of admission for asthma and COPD. In the Post-COVID-19 outbreak period, the overall cumulative relationship between PM and PM and respiratory diseases and the effects of extreme levels of PM and PM on respiratory diseases were completely changed. For non-respiratory diseases, PM and PM were statistically insignificant for admission risk during both periods. Our study may provide evidence that implementing NPIs and reducing PM and PM exposure during the COVID-19 pandemic has contributed to reducing hospital admissions for environment-based respiratory diseases.
本研究旨在探讨 COVID-19 非药物干预(NPIs)对韩国六个大都市地区空气污染物与呼吸和非呼吸疾病住院之间关系的影响。本研究通过使用分布式滞后非线性模型,比较了 COVID-19 NPI 实施前后(2016-2019 年和 2020 年),细颗粒物(PM 和 PM )与呼吸和非呼吸疾病住院之间的关联。在 COVID-19 前时期,PM 与哮喘和 COPD 住院风险之间的关联呈倒 U 型模式。对于 PM ,哮喘和 COPD 分别观察到 S 型和倒 U 型变化。极高和极低水平的 PM 和极低水平的 PM 显著降低了哮喘和 COPD 的住院风险。在 COVID-19 爆发后时期,PM 和 PM 与呼吸疾病的整体累积关系以及极端水平的 PM 和 PM 对呼吸疾病的影响完全改变。对于非呼吸疾病,PM 和 PM 在两个时期的入院风险均无统计学意义。本研究可能为实施 NPI 和减少 COVID-19 大流行期间 PM 和 PM 暴露有助于降低基于环境的呼吸疾病住院率提供证据。