Modelling and optimization of membrane process for removal of biologics (pathogens) from water and wastewater: Current perspectives and challenges.

As one of the 17 sustainable development goals, the United Nations (UN) has prioritized "clean water and sanitation" (Goal 6) to reduce the discharge of emerging pollutants and disease-causing agents into the environment. Contamination of water by pathogenic microorganisms and their existence in treated water is a global public health concern. Under natural conditions, water is frequently prone to contamination by invasive microorganisms, such as bacteria, viruses, and protozoa. This circumstance has therefore highlighted the critical need for research techniques to prevent, treat, and get rid of pathogens in wastewater. Membrane systems have emerged as one of the effective ways of removing contaminants from water and wastewater However, few research studies have examined the synergistic or conflicting effects of operating conditions on newly developing contaminants found in wastewater. Therefore, the efficient, dependable, and expeditious examination of the pathogens in the intricate wastewater matrix remains a significant obstacle. As far as it can be ascertained, much attention has not recently been given to optimizing membrane processes to develop optimal operation design as related to pathogen removal from water and wastewater. Therefore, this state-of-the-art review aims to discuss the current trends in removing pathogens from wastewater by membrane techniques. In addition, conventional techniques of treating pathogenic-containing water and wastewater and their shortcomings were briefly discussed. Furthermore, derived mathematical models suitable for modelling, simulation, and control of membrane technologies for pathogens removal are highlighted. In conclusion, the challenges facing membrane technologies for removing pathogens were extensively discussed, and future outlooks/perspectives on optimizing and modelling membrane processes are recommended.