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结肠腺癌中Trpa1和Trpc1免疫反应性的研究

Investigation of Trpa1 and Trpc1 Immunreactivities in Colon Adenocarcinomas.

作者信息

Bozdag Ahmet, Kuloglu Tuncay, Artas Gokhan, Aydin Suleyman

机构信息

Department of General Surgery, School of Medicine, Firat University, Elazig, Turkey.

Department of Histology and Embryology, School of Medicine, Firat University, Elazig, Turkey.

出版信息

Cancer Manag Res. 2024 Apr 24;16:377-384. doi: 10.2147/CMAR.S447549. eCollection 2024.

DOI:10.2147/CMAR.S447549
PMID:38699653
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11063473/
Abstract

PURPOSE

As the normal colon epithelium differentiates into adenoma, invasive cancer and metastatic cancer, the cell acquires new characteristics such as apoptosis, proliferation, differentiation, invasion and metastasis. Many mechanisms are effective in acquiring these qualities. One of these is the regulation of the functioning of ion channels. This study aimed to examine TRPA1 and TRPC1 expression in colorectal adenocarcinomas showing different degrees of differentiation.

PATIENTS AND METHODS

We examined the biopsy specimens of 60 patients diagnosed with colorectal adenocarcinomas, including those of patients with well-differentiated (n = 20), moderately differentiated (n = 20) and poorly differentiated (n = 20) carcinomas. Moreover, 20 biopsy specimens of individuals with normal colonic mucosa were examined. Histoscores were calculated for TRPA1 and TRPC1 based on the extent of diffusion and intensity of immunoreactivity, and these scores were compared statistically.

RESULTS

A statistically significant increase in both TRPA1 and TRPC1 immunoreactivity was observed in low-grade and high-grade colon adenocarcinomas compared to the control group (p<0.001). A statistically significant decrease in both TRPA1 and TRPC1 immunoreactivity was observed in high-grade colon adenocarcinomas compared to low-grade colon adenocarcinomas (p<0.001).

CONCLUSION

TRPA1 and TRPC1 immunoreactivites are increased in colorectal adenocarcinoma tissue compared with the healthy tissue. Furthermore, the immunoreactivity decreases as the grade of cancer increases.

摘要

目的

随着正常结肠上皮细胞分化为腺瘤、浸润性癌和转移性癌，细胞会获得诸如凋亡、增殖、分化、侵袭和转移等新特性。许多机制在获得这些特性方面发挥作用。其中之一是离子通道功能的调节。本研究旨在检测不同分化程度的结直肠癌中TRPA1和TRPC1的表达。

患者及方法

我们检测了60例诊断为结直肠癌患者的活检标本，包括高分化（n = 20）、中分化（n = 20）和低分化（n = 20）癌患者的标本。此外，还检测了20例正常结肠黏膜个体的活检标本。根据TRPA1和TRPC1的扩散程度和免疫反应强度计算组织学评分，并对这些评分进行统计学比较。

结果

与对照组相比（p<0.001），在低级别和高级别结肠腺癌中均观察到TRPA1和TRPC1免疫反应性有统计学意义的增加。与低级别结肠腺癌相比，高级别结肠腺癌中TRPA1和TRPC1免疫反应性均有统计学意义的降低（p<0.001）。

结论

与健康组织相比，结直肠癌组织中TRPA1和TRPC1免疫反应性增加。此外，免疫反应性随癌症分级增加而降低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03f2/11063473/747a6234e398/CMAR-16-377-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03f2/11063473/76c026c6425f/CMAR-16-377-g0001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03f2/11063473/c70287e90b58/CMAR-16-377-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03f2/11063473/6f4522c3f22c/CMAR-16-377-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03f2/11063473/98f6545c906b/CMAR-16-377-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03f2/11063473/9705dcee4438/CMAR-16-377-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03f2/11063473/ef506bd49053/CMAR-16-377-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03f2/11063473/747a6234e398/CMAR-16-377-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03f2/11063473/76c026c6425f/CMAR-16-377-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03f2/11063473/bee84dc9f3f8/CMAR-16-377-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03f2/11063473/c70287e90b58/CMAR-16-377-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03f2/11063473/6f4522c3f22c/CMAR-16-377-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03f2/11063473/98f6545c906b/CMAR-16-377-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03f2/11063473/9705dcee4438/CMAR-16-377-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03f2/11063473/ef506bd49053/CMAR-16-377-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03f2/11063473/747a6234e398/CMAR-16-377-g0008.jpg

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