Gu Xiaojing, Chen Hu, Li Rongping, Guo Dibin
The First Affiliated Hospital of Gannan Medical College, Department of Rheumatology and Immunology, Ganzhou, China.
J Med Biochem. 2024 Apr 23;43(2):265-272. doi: 10.5937/jomb0-45870.
Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease characterized by multi-organ multi-system inflammation, causing severe damage to various organs or systems. Recent studies have shown that miR-155 can affect the progression of Lupus Nephritis via regulating TNF-a. The present study aims to explore the roles of MIR155HG and TNF-a in the evaluation of prognosis of patients with SLE, so as to provide a basis for clinical work.
A total of 130 patients with SLE admitted to our hospital were selected, were selected from June 2015 to December 2017., and the SLE disease activity index (SLEDAI) score was given. The expressions of MIR155HG and TNF-a were detected via quantitative reverse transcription-polymerase chain reaction (qRT-PCR), the incidence of complications during treatment was observed, and the associations of MIR155HG and TNF-a with SLEDAI before treatment and complications were analyzed. All patients were followed up after discharge, and the related factors to the prognosis of patients were analyzed via Cox regression analysis.
The levels of MIR155HG and TNF-a were higher in patients with an SLEDAI score of 10-14 points than those in patients with an SLEDAI score of 5-9 points and 0-4 points. MIR155HG and TNF-a were positively correlated with the incidence of infection, renal damage and cardiac damage (r=0.623, 0.533 and 0.621; r=0.431, 0.498 and 0.552) (P<0.05). Moreover, there was also a positive correlation (r=0.3398, P<0.001) between the expressions of serum MIR155HG and TNF-a in SLE patients. SLEDAI score ≥10 points, complications during hospitalization, and highly-expressed MIR155HG and TNFa were risk factors related to the prognosis of patients.
MIR155HG and TNF-a affect the activity of SLE, and the high expressions of them promote the occurrence of such complications as infection, renal damage and cardiac damage, harming the prognosis.
系统性红斑狼疮（SLE）是一种慢性炎症性自身免疫性疾病，其特征为多器官多系统炎症，会对多个器官或系统造成严重损害。最近的研究表明，miR - 155可通过调节肿瘤坏死因子 - a（TNF - a）来影响狼疮性肾炎的进展。本研究旨在探讨MIR155HG和TNF - a在评估SLE患者预后中的作用，以便为临床工作提供依据。
选取2015年6月至2017年12月我院收治的130例SLE患者，给予SLE疾病活动指数（SLEDAI）评分。通过定量逆转录 - 聚合酶链反应（qRT - PCR）检测MIR155HG和TNF - a的表达，观察治疗期间并发症的发生率，并分析MIR155HG和TNF - a与治疗前SLEDAI及并发症的相关性。所有患者出院后进行随访，通过Cox回归分析患者预后的相关因素。
SLEDAI评分为10 - 14分的患者中MIR155HG和TNF - a水平高于SLEDAI评分为5 - 9分和0 - 4分的患者。MIR155HG和TNF - a与感染、肾损害及心脏损害的发生率呈正相关（r = 0.623、0.533和0.621；r = 0.431、0.498和0.552）（P < 0.05）。此外，SLE患者血清MIR155HG与TNF - a的表达之间也呈正相关（r = 0.3398，P < 0.001）。SLEDAI评分≥10分、住院期间并发症以及MIR155HG和TNF - a高表达是与患者预后相关的危险因素。
MIR155HG和TNF - a影响SLE的活动度，它们的高表达促进感染、肾损害和心脏损害等并发症的发生，对预后产生不良影响。
