氮杂芳烃与甲醇的电助光催化羟甲基化反应
Electrophotocatalytic Hydroxymethylation of Azaarenes with Methanol.
作者信息
Quevedo-Flores Beatriz, Bosque Irene, Gonzalez-Gomez Jose C
机构信息
Instituto de Síntesis Orgánica (ISO) and Departamento de Química Orgánica, Universidad de Alicante, 03080 San Vicente del Raspeig, Spain.
出版信息
Org Lett. 2024 Sep 6;26(35):7447-7451. doi: 10.1021/acs.orglett.4c02797. Epub 2024 Aug 24.
The merging of electrochemistry and photocatalysis allowed the required selectivity for the hydroxymethylation of functionalized azaarenes with methanol, including bioactive substrates. The two electrophotocatalytic protocols developed in this work address this transformation, using nontoxic and readily available reagents under mild reaction conditions with electricity as the only "sacrificial oxidant".
电化学与光催化的结合使得对功能化氮杂芳烃与甲醇进行羟甲基化反应（包括生物活性底物）所需的选择性成为可能。本研究中开发的两种光电催化方法解决了这一转化问题，在温和的反应条件下使用无毒且易于获得的试剂，仅以电作为“牺牲性氧化剂”。
Zotero 插件