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Eur Respir J. 2025 Apr 3;65(4). doi: 10.1183/13993003.01407-2024. Print 2025 Apr.
2
An integrated cell atlas of the lung in health and disease.肺部健康与疾病的细胞整合图谱
Nat Med. 2023 Jun;29(6):1563-1577. doi: 10.1038/s41591-023-02327-2. Epub 2023 Jun 8.
3
A specialized integrin-binding motif enables proTGF-β2 activation by integrin αVβ6 but not αVβ8.一种特殊的整合素结合基序使 proTGF-β2 能够被整合素 αVβ6 而不是 αVβ8 激活。
Proc Natl Acad Sci U S A. 2023 Jun 13;120(24):e2304874120. doi: 10.1073/pnas.2304874120. Epub 2023 Jun 6.
4
Dupilumab for COPD with Type 2 Inflammation Indicated by Eosinophil Counts.针对嗜酸性粒细胞计数提示 2 型炎症的 COPD，应用度普利尤单抗。
N Engl J Med. 2023 Jul 20;389(3):205-214. doi: 10.1056/NEJMoa2303951. Epub 2023 May 21.
5
Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk.多祖裔全基因组关联分析提高了影响肺功能和慢性阻塞性肺疾病风险的基因和通路的分辨率。
Nat Genet. 2023 Mar;55(3):410-422. doi: 10.1038/s41588-023-01314-0. Epub 2023 Mar 13.
6
A Unique Cellular Organization of Human Distal Airways and Its Disarray in Chronic Obstructive Pulmonary Disease.人类远端气道的独特细胞组织及其在慢性阻塞性肺疾病中的紊乱。
Am J Respir Crit Care Med. 2023 May 1;207(9):1171-1182. doi: 10.1164/rccm.202207-1384OC.
7
Nephronectin is required to maintain right lung lobar separation during embryonic development.肾胞蛋白在胚胎发育过程中对维持右肺叶的分离起重要作用。
Am J Physiol Lung Cell Mol Physiol. 2023 Mar 1;324(3):L335-L344. doi: 10.1152/ajplung.00505.2021. Epub 2023 Jan 31.
8
The NHGRI-EBI GWAS Catalog: knowledgebase and deposition resource.NHGRI-EBI GWAS 目录：知识库和存储资源。
Nucleic Acids Res. 2023 Jan 6;51(D1):D977-D985. doi: 10.1093/nar/gkac1010.
9
Human distal lung maps and lineage hierarchies reveal a bipotent progenitor.人类远端肺图谱和谱系层次结构揭示了一个双能祖细胞。
Nature. 2022 Apr;604(7904):111-119. doi: 10.1038/s41586-022-04541-3. Epub 2022 Mar 30.
10
Human distal airways contain a multipotent secretory cell that can regenerate alveoli.人类远端气道中存在一种多能分泌细胞，它可以再生肺泡。
Nature. 2022 Apr;604(7904):120-126. doi: 10.1038/s41586-022-04552-0. Epub 2022 Mar 30.

Molecular Characterization of the Distal Lung: Novel Insights from Chronic Obstructive Pulmonary Disease Omics.

作者信息

Castaldi Peter J, Sauler Maor

机构信息

Channing Division of Network Medicine and.

Division of General Internal Medicine and Primary Care, Brigham and Women's Hospital, Boston, Massachusetts; and.

出版信息

Am J Respir Crit Care Med. 2024 Jul 15;210(2):147-154. doi: 10.1164/rccm.202310-1972PP.

DOI:10.1164/rccm.202310-1972PP
PMID:38701385
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11273319/
Abstract
摘要