甘油三酯-葡萄糖指数作为胰岛素抵抗、糖尿病、代谢综合征和心血管疾病的生物标志物：综述
Triglyceride-Glucose Index As A Biomarker Of Insulin Resistance, Diabetes Mellitus, Metabolic Syndrome, And Cardiovascular Disease: A Review.
作者信息
Kurniawan Liong Boy
机构信息
Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
出版信息
EJIFCC. 2024 Apr 11;35(1):44-51. eCollection 2024 Apr.
Abstract
The triglyceride-glucose (TyG) index is one of the parameters that have been used in assessing insulin resistance. Triglycerides and fasting blood glucose are two low-cost, common laboratory indicators that are used to compute the TyG index. This article reviews the link between the TyG index and several aspects concerning insulin resistance-related disorders and cardiovascular disease, as well as the use of various TyG index cutoffs in the above conditions with sensitivity and specificity, respectively, in various populations in the world.
摘要
甘油三酯-葡萄糖（TyG）指数是用于评估胰岛素抵抗的参数之一。甘油三酯和空腹血糖是用于计算TyG指数的两个低成本、常见的实验室指标。本文综述了TyG指数与胰岛素抵抗相关疾病和心血管疾病的几个方面之间的联系，以及在上述情况下，TyG指数在世界不同人群中的不同临界值分别具有的敏感性和特异性。
相似文献
1
Triglyceride-Glucose Index As A Biomarker Of Insulin Resistance, Diabetes Mellitus, Metabolic Syndrome, And Cardiovascular Disease: A Review.
EJIFCC. 2024 Apr 11;35(1):44-51. eCollection 2024 Apr.
2
Association of the triglyceride glucose index as a measure of insulin resistance with mortality and cardiovascular disease in populations from five continents (PURE study): a prospective cohort study.
Lancet Healthy Longev. 2023 Jan;4(1):e23-e33. doi: 10.1016/S2666-7568(22)00247-1. Epub 2022 Dec 12.
3
Triglyceride glucose (TyG) index: A promising biomarker for diagnosis and treatment of different diseases.
Eur J Intern Med. 2025 Jan;131:3-14. doi: 10.1016/j.ejim.2024.08.026. Epub 2024 Oct 29.
4
Comparison of the Effects of Fasting Glucose, Hemoglobin A, and Triglyceride-Glucose Index on Cardiovascular Events in Type 2 Diabetes Mellitus.
Nutrients. 2019 Nov 19;11(11):2838. doi: 10.3390/nu11112838.
5
Elevated Triglyceride-Glucose Index Is Associated With Insulin Resistance, Metabolic Syndrome Components, Nonalcoholic Fatty Liver Disease, and Adverse Pregnancy Outcomes in Chinese Women With Polycystic Ovary Syndrome.
Clin Endocrinol (Oxf). 2025 Apr 29. doi: 10.1111/cen.15252.
6
Triglyceride-Glucose Index (TyG) is associated with erectile dysfunction: A cross-sectional study.
Andrology. 2021 Jan;9(1):238-244. doi: 10.1111/andr.12904. Epub 2020 Oct 19.
7
Comparison of triglyceride glucose index and HbA1C as a marker of prediabetes - A preliminary study.
Diabetes Metab Syndr. 2022 Sep;16(9):102605. doi: 10.1016/j.dsx.2022.102605. Epub 2022 Aug 24.
8
The role of the triglyceride-glucose index as a biomarker of cardio-metabolic syndromes.
Lipids Health Dis. 2024 Dec 23;23(1):416. doi: 10.1186/s12944-024-02412-6.
9
The triglyceride-glucose index is superior to homeostasis model assessment of insulin resistance in predicting metabolic syndrome in an adult population in the United States.
J Clin Lipidol. 2024 Jul-Aug;18(4):e518-e524. doi: 10.1016/j.jacl.2024.04.130. Epub 2024 Apr 24.
10
Triglyceride glucose index for the detection of asymptomatic coronary artery stenosis in patients with type 2 diabetes.
Cardiovasc Diabetol. 2020 Sep 12;19(1):137. doi: 10.1186/s12933-020-01108-2.
引用本文的文献
1
Correlation of the triglyceride-glucose index with major adverse cardiovascular events in type 2 diabetes mellitus patients with acute myocardial infarction combined with HFpEF.
Front Endocrinol (Lausanne). 2025 Aug 26;16:1585067. doi: 10.3389/fendo.2025.1585067. eCollection 2025.
2
Comparison of nine insulin resistance surrogates for predicting cardiovascular disease: a cohort study.
Diabetol Metab Syndr. 2025 Aug 31;17(1):365. doi: 10.1186/s13098-025-01933-z.
3
Associations of the fasting triglyceride glucose index with pulse wave velocity vary by age and gender.
Arch Endocrinol Metab. 2025 Aug 20;69(4):e250115. doi: 10.20945/2359-4292-2025-0115.
4
Association between triglyceride-glucose index and vitamin D levels in Saudi postmenopausal women: a cross-sectional study.
Int J Clin Exp Pathol. 2025 Jul 15;18(7):375-385. doi: 10.62347/GMTV5559. eCollection 2025.
5
The relationship between the triglyceride-glucose index and lung function in healthy individuals: a cross-sectional study of 89,809 participants from Kangbuk Samsung health study.
BMC Pulm Med. 2025 Aug 9;25(1):383. doi: 10.1186/s12890-025-03869-6.
6
Crosstalk Between Metabolic Biomarkers and Pulse Wave Analysis in Hypertensive Patients.
Biomedicines. 2025 Jun 20;13(7):1514. doi: 10.3390/biomedicines13071514.
7
Atherosclerosis and Insulin Resistance: Is There a Link Between Them?
Biomedicines. 2025 May 23;13(6):1291. doi: 10.3390/biomedicines13061291.
8
Left Ventricular Systolic Function in Asymptomatic Men Aged 65-75 Years, Relation to Insulin Resistance and Pre-Diabetes: A DANCAVAS Cross-Sectional Sub-Study.
J Cardiovasc Dev Dis. 2025 May 13;12(5):180. doi: 10.3390/jcdd12050180.
9
Lipid Subclasses Differentiate Insulin Resistance by Triglyceride-Glucose Index.
Metabolites. 2025 May 20;15(5):342. doi: 10.3390/metabo15050342.
10
Risk of Insulin Resistance: Comparison of the Commerce vs. Industry Sector and Associated Variables.
Diseases. 2025 May 14;13(5):150. doi: 10.3390/diseases13050150.
本文引用的文献
1
Triglyceride-Glucose Index Linked to In-Hospital Mortality in Critically Ill Patients with Heart Disease.
Rev Cardiovasc Med. 2022 Jul 21;23(8):263. doi: 10.31083/j.rcm2308263. eCollection 2022 Aug.
2
Evaluation of Triglyceride Glucose Index and Homeostasis Model of Insulin Resistance in Patients with Polycystic Ovary Syndrome.
Int J Womens Health. 2022 Dec 23;14:1821-1829. doi: 10.2147/IJWH.S387942. eCollection 2022.
3
Triglyceride Glucose Index is Related with the Risk of Mild Cognitive Impairment in Type 2 Diabetes.
Diabetes Metab Syndr Obes. 2022 Nov 18;15:3577-3587. doi: 10.2147/DMSO.S389327. eCollection 2022.
4
Relationship Between the Triglyceride-Glucose Index and Type 2 Diabetic Macroangiopathy: A Single-Center Retrospective Analysis.
Diabetes Metab Syndr Obes. 2022 Nov 9;15:3483-3497. doi: 10.2147/DMSO.S387040. eCollection 2022.
5
The Global Burden of Cardiovascular Diseases and Risk: A Compass for Future Health.
J Am Coll Cardiol. 2022 Dec 20;80(25):2361-2371. doi: 10.1016/j.jacc.2022.11.005. Epub 2022 Nov 9.
6
The accuracy of triglyceride-glucose (TyG) index for the screening of metabolic syndrome in adults: A systematic review and meta-analysis.
Nutr Metab Cardiovasc Dis. 2022 Dec;32(12):2677-2688. doi: 10.1016/j.numecd.2022.07.024. Epub 2022 Sep 2.
7
Elevated triglyceride-glucose (TyG) index predicts impaired islet β-cell function: A hospital-based cross-sectional study.
Front Endocrinol (Lausanne). 2022 Sep 30;13:973655. doi: 10.3389/fendo.2022.973655. eCollection 2022.
8
Triglyceride-Glucose Index for the Diagnosis of Metabolic Syndrome: A Cross-Sectional Study of 298,652 Individuals Receiving a Health Check-Up in China.
Int J Endocrinol. 2022 Jun 29;2022:3583603. doi: 10.1155/2022/3583603. eCollection 2022.
9
Trends in insulin resistance: insights into mechanisms and therapeutic strategy.
Signal Transduct Target Ther. 2022 Jul 6;7(1):216. doi: 10.1038/s41392-022-01073-0.
10
Triglyceride-Glucose Index Is a Useful Marker for Predicting Future Cardiovascular Disease and Mortality in Young Korean Adults: A Nationwide Population-Based Cohort Study.
J Lipid Atheroscler. 2022 May;11(2):178-186. doi: 10.12997/jla.2022.11.2.178. Epub 2022 Apr 21.
Zotero 插件