Strain dependence of muramyl dipeptide-induced LAF(IL 1) release by murine-adherent peritoneal cells.

The capacity of MDP to stimulate LAF(IL 1) production by adherent peritoneal cells (APC) from different strains of mice was examined. It was observed that MDP could stimulate thioglycollate-induced APC from DBA/2, C57B1/6, and CBA/CA mice, but not from C3H mice. Resident APC from DBA/2 or C3H/HeJ mice were also responders and nonresponders, respectively, to MDP for LAF(IL 1) production, the positive effect of MDP being more marked on DBA/2 cells in the presence of indomethacin. Because a LPS high-responder C3H substrain (C3HeB/Fe) did not respond to MDP, it was concluded that the strain dependence with respect to the induction of LAF(IL 1) seen with both MDP and LPS was not linked. Moreover, the unresponsiveness of C3H mice to MDP was not linked to their MHC haplotype, because a second H-2k strain (CBA/CA) was a good responder to MDP stimulation.