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老年人的衰老速度对健康寿命和寿命至关重要。

Pace of Aging in older adults matters for healthspan and lifespan.

作者信息

Balachandran A, Pei H, Shi Y, Beard J, Caspi A, Cohen A, Domingue B W, Eckstein Indik C, Ferrucci L, Furuya A, Kothari M, Moffitt T E, Ryan C, Skirbekk V, Zhang Y, Belsky D W

机构信息

Robert N Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, USA.

Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA.

出版信息

medRxiv. 2024 Nov 12:2024.04.25.24306359. doi: 10.1101/2024.04.25.24306359.

DOI:10.1101/2024.04.25.24306359
PMID:38712264
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11071564/
Abstract

As societies age, policy makers need tools to understand how demographic aging will affect population health and to develop programs to increase healthspan. The current metrics used for policy analysis do not distinguish differences caused by early-life factors, such as prenatal care and nutrition, from those caused by ongoing changes in people's bodies due to aging. Here we introduce an adapted Pace of Aging method designed to quantify differences between individuals and populations in the speed of aging-related health declines. The adapted Pace of Aging method, implemented in data from the US Health and Retirement Study and English Longitudinal Study of Aging (N=21,463), integrates longitudinal data on blood biomarkers, physical measurements, and functional tests. It reveals stark differences in rates of aging between population subgroups and demonstrates strong and consistent prospective associations with incident morbidity, disability, and mortality. Pace of Aging can advance the population science of healthy longevity.

摘要

随着社会老龄化，政策制定者需要工具来了解人口老龄化将如何影响人口健康，并制定计划以延长健康寿命。目前用于政策分析的指标无法区分由早期生活因素（如产前护理和营养）引起的差异与由于衰老导致的人体持续变化所引起的差异。在此，我们引入一种经过改进的衰老速度方法，旨在量化个体和人群在与衰老相关的健康衰退速度方面的差异。这种经过改进的衰老速度方法应用于美国健康与退休研究以及英国老龄化纵向研究的数据（N = 21,463），整合了血液生物标志物、身体测量和功能测试的纵向数据。它揭示了不同人群亚组之间衰老速度的显著差异，并显示出与发病、残疾和死亡事件之间强烈且一致的前瞻性关联。衰老速度可以推动健康长寿的人口科学发展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84c9/11563247/aa7656c9dd42/nihpp-2024.04.25.24306359v2-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84c9/11563247/678a7e26f6c3/nihpp-2024.04.25.24306359v2-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84c9/11563247/310ab70a01d1/nihpp-2024.04.25.24306359v2-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84c9/11563247/72bbc1668a91/nihpp-2024.04.25.24306359v2-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84c9/11563247/9ba6abf00290/nihpp-2024.04.25.24306359v2-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84c9/11563247/aa7656c9dd42/nihpp-2024.04.25.24306359v2-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84c9/11563247/678a7e26f6c3/nihpp-2024.04.25.24306359v2-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84c9/11563247/310ab70a01d1/nihpp-2024.04.25.24306359v2-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84c9/11563247/72bbc1668a91/nihpp-2024.04.25.24306359v2-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84c9/11563247/9ba6abf00290/nihpp-2024.04.25.24306359v2-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84c9/11563247/aa7656c9dd42/nihpp-2024.04.25.24306359v2-f0005.jpg

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本文引用的文献

1
The Dunedin study after half a century: reflections on the past, and course for the future.半个世纪后的达尼丁研究：对过去的反思与未来的方向
J R Soc N Z. 2022 Sep 7;53(4):446-465. doi: 10.1080/03036758.2022.2114508. eCollection 2023.
2
Dried blood spot based biomarkers in the Health and Retirement Study: 2006 to 2016.基于血斑的生物标志物在健康与退休研究中的应用：2006 年至 2016 年。
Am J Hum Biol. 2024 Feb;36(2):e23997. doi: 10.1002/ajhb.23997. Epub 2023 Oct 6.
3
A complex systems approach to aging biology.一种用于衰老生物学的复杂系统方法。
Nat Aging. 2022 Jul;2(7):580-591. doi: 10.1038/s43587-022-00252-6. Epub 2022 Jul 20.
4
Longitudinal phenotypic aging metrics in the Baltimore Longitudinal Study of Aging.巴尔的摩纵向衰老研究中的纵向表型衰老指标。
Nat Aging. 2022 Jul;2(7):635-643. doi: 10.1038/s43587-022-00243-7. Epub 2022 Jul 18.
5
In utero exposure to the Great Depression is reflected in late-life epigenetic aging signatures.子宫内暴露于大萧条时期会反映在晚年的表观遗传衰老特征中。
Proc Natl Acad Sci U S A. 2022 Nov 15;119(46):e2208530119. doi: 10.1073/pnas.2208530119. Epub 2022 Nov 8.
6
The health-adjusted dependency ratio as a new global measure of the burden of ageing: a population-based study.健康调整后的依赖比率作为衡量老龄化负担的新全球指标：基于人口的研究。
Lancet Healthy Longev. 2022 May;3(5):e332-e338. doi: 10.1016/S2666-7568(22)00075-7. Epub 2022 May 4.
7
Social mobility and biological aging among older adults in the United States.美国老年人的社会流动性与生物衰老
PNAS Nexus. 2022 Mar 29;1(2):pgac029. doi: 10.1093/pnasnexus/pgac029. eCollection 2022 May.
8
Expansion, Compression, Neither, Both? Divergent Patterns in Healthy, Disability-Free, and Morbidity-Free Life Expectancy Across U.S. Birth Cohorts, 1998-2016.扩展、压缩、两者皆无、两者皆有？1998-2016 年美国出生队列中健康、无残疾和无病态预期寿命的不同模式。
Demography. 2022 Jun 1;59(3):949-973. doi: 10.1215/00703370-9938662.
9
DunedinPACE, a DNA methylation biomarker of the pace of aging.多恩比恩衰老速度预测指标（DunedinPACE），一种衰老速度的 DNA 甲基化生物标志物。
Elife. 2022 Jan 14;11:e73420. doi: 10.7554/eLife.73420.
10
Associations Between Life-Course Socioeconomic Conditions and the Pace of Aging.生命历程中的社会经济状况与衰老速度之间的关联。
J Gerontol A Biol Sci Med Sci. 2022 Nov 21;77(11):2257-2264. doi: 10.1093/gerona/glab383.