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通过血液检测，即 DunedinPoAm DNA 甲基化算法，对人类生物衰老的速度进行量化。

Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm.

机构信息

Department of Epidemiology, Columbia University Mailman School of Public Health, New York, United States.

Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, United States.

出版信息

Elife. 2020 May 5;9:e54870. doi: 10.7554/eLife.54870.

DOI:10.7554/eLife.54870
PMID:32367804
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7282814/
Abstract

Biological aging is the gradual, progressive decline in system integrity that occurs with advancing chronological age, causing morbidity and disability. Measurements of the pace of aging are needed as surrogate endpoints in trials of therapies designed to prevent disease by slowing biological aging. We report a blood-DNA-methylation measure that is sensitive to variation in pace of biological aging among individuals born the same year. We first modeled change-over-time in 18 biomarkers tracking organ-system integrity across 12 years of follow-up in n = 954 members of the Dunedin Study born in 1972-1973. Rates of change in each biomarker over ages 26-38 years were composited to form a measure of aging-related decline, termed Pace-of-Aging. Elastic-net regression was used to develop a DNA-methylation predictor of Pace-of-Aging, called DunedinPoAm for Dunedin(P)ace(o)f(A)ging(m)ethylation. Validation analysis in cohort studies and the CALERIE trial provide proof-of-principle for DunedinPoAm as a single-time-point measure of a person's pace of biological aging.

摘要

生物衰老指的是随着年龄增长，系统完整性逐渐、渐进地下降，从而导致发病和残疾。在旨在通过减缓生物衰老来预防疾病的治疗方法的试验中，需要使用衰老速度的测量值作为替代终点。我们报告了一种血液 DNA 甲基化测量方法，该方法可以敏感地反映出同一年出生的个体之间生物衰老速度的差异。我们首先对 18 个生物标志物进行了建模，这些标志物在 12 年的随访期间跟踪了 12 个器官系统的完整性，研究对象为 1972 年至 1973 年出生的达尼丁研究中的 954 名成员。每个生物标志物在 26-38 岁之间的变化率被综合起来，形成了一个与衰老相关的下降指标，称为衰老速度（Pace-of-Aging）。弹性网络回归用于开发一种 DNA 甲基化预测衰老速度的方法，称为 DunedinPoAm（达尼丁[P]ace[o]f[A]ging[甲基化]）。在队列研究和 CALERIE 试验中的验证分析为 DunedinPoAm 作为一个人生物学衰老速度的单次测量方法提供了原理验证。

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