B 淋巴细胞白血病中的 3 号染色体缺失（3)(p13)——一种可能与 c-ras 癌基因相关的新的非随机染色体畸变。
Del(3)(p13) in B-prolymphocytic leukemia--a new nonrandom chromosomal aberration possibly related to the c-ras oncogene.
作者信息
Juliusson G, Robèrt K H, Ost A, Friberg K, Biberfeld P, Zech L, Gahrton G
出版信息
Cancer Genet Cytogenet. 1985 Jan 15;14(3-4):191-5. doi: 10.1016/0165-4608(85)90184-0.
Cytogenetic analysis was performed on the leukemic cells from two patients with B-prolymphocytic leukemia. Both patients had del(3)(p13) chromosomal abnormality, as well as other clonal aberrations. Del(3p) was previously reported in one case of B-cell prolymphocytic leukemia, and is known to be a specific aberration in small-cell carcinoma of the lung. In B-cell prolymphocytic leukemia, as in other B-lymphocytic leukemias/lymphomas, the karyotype often involves chromosomes #3, #6, #11, and #12. All of these chromosomes are suggested sites for the c-ras oncogene family.
对两名B-前淋巴细胞白血病患者的白血病细胞进行了细胞遗传学分析。两名患者均有del(3)(p13)染色体异常以及其他克隆性畸变。del(3p)先前在1例B细胞前淋巴细胞白血病中被报道过，并且已知是肺小细胞癌的一种特异性畸变。在B细胞前淋巴细胞白血病中，如同在其他B淋巴细胞白血病/淋巴瘤中一样，核型常涉及3号、6号、11号和12号染色体。所有这些染色体均被认为是c-ras癌基因家族的位点。
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