Longnecker D S, Roebuck B D, Kuhlmann E T, Curphey T J
J Natl Cancer Inst. 1985 Jan;74(1):209-17.
The carcinogenicity of N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine (HPOP) for rat pancreas was evaluated. Two-week-old male LEW rats were given a single ip injection of HPOP, 160 mg/kg body weight; the rats were autopsied 4, 6, or 12 months later. Histologic examination showed that the pancreata contained multiple foci of atypical acinar cells and nodules of atypical acinar cells (AACN), acinar cell adenomas, localized carcinomas, and carcinomas. The incidence of carcinomas was 77%. The carcinomas were composed of poorly differentiated acinar cells and ductlike structures. Pancreatic ducts were unaffected. The prominence of AACN, the histologic type of the neoplasms, and the absence of hyperplastic changes in ductal epithelium suggest that the pancreatic carcinomas were derived from acinar cells. The incidence of liver cell carcinomas and pulmonary adenomas was similar to that of localized pancreatic carcinomas. Neoplasms of other organs were less frequent. HPOP has been shown to induce pancreatic carcinomas in hamsters but has not previously been reported to be a pancreatic carcinogen in rats.
评估了N-亚硝基(2-羟丙基)(2-氧代丙基)胺(HPOP)对大鼠胰腺的致癌性。给2周龄雄性LEW大鼠腹腔注射一次HPOP，剂量为160mg/kg体重；4、6或12个月后对大鼠进行解剖。组织学检查显示，胰腺含有多个非典型腺泡细胞灶和非典型腺泡细胞结节(AACN)、腺泡细胞腺瘤、局部癌和癌。癌的发生率为77%。癌由低分化腺泡细胞和导管样结构组成。胰管未受影响。AACN的突出、肿瘤的组织学类型以及导管上皮无增生性改变表明胰腺癌起源于腺泡细胞。肝细胞癌和肺腺瘤的发生率与局部胰腺癌相似。其他器官的肿瘤较少见。已证明HPOP可在仓鼠中诱发胰腺癌，但此前尚未报道其为大鼠胰腺致癌物。
