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用于癌症治疗的传统中医

Traditional Chinese Medicine for Cancer Treatment.

作者信息

Liu Yangli, Fang Cheng, Luo Jiaojiao, Gong Chenyuan, Wang Lixin, Zhu Shiguo

机构信息

Department of Immunology and Pathogenic Biology, School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, P. R. China.

出版信息

Am J Chin Med. 2024;52(3):583-604. doi: 10.1142/S0192415X24500253. Epub 2024 May 8.

Abstract

In recent years, due to advancements in medical conditions and the development of scientific research, the fundamental research of TCM antitumor treatments has progressed from the cellular level to the molecular and genetic levels. Previous studies have demonstrated the significant role of traditional Chinese medicine (TCM) in antitumor therapy through various mechanisms and pathways. Its mechanism of action is closely associated with cancer biology across different stages. This includes inhibiting tumor cell proliferation, blocking invasion and metastasis to surrounding tissues, inducing tumor cell apoptosis, inhibiting tumor angiogenesis, regulating immune function, maintaining genome stability, preventing mutation, and regulating cell energy metabolism. The use of TCM for eliciting antitumor effects not only has a good therapeutic effect and low side effects, it also provides a solid theoretical basis for clinical treatment and medication. This paper reviews the mechanism of the antitumor effects of TCM based on tumor characteristics. Through our review, we found that TCM not only directly inhibits tumors, but also enhances the body's immunity, thereby indirectly inducing an antitumor effect. This function aligns with the TCM theory of "strengthening the body's resistance to eliminate pathogenic factors". Furthermore, TCM will play a significant role in tumor treatment in clinical settings.

摘要

近年来,由于医疗条件的进步和科学研究的发展,中医抗肿瘤治疗的基础研究已从细胞水平发展到分子和基因水平。以往的研究已经证明了中药在抗肿瘤治疗中通过各种机制和途径发挥的重要作用。其作用机制与癌症不同阶段的生物学密切相关。这包括抑制肿瘤细胞增殖、阻断向周围组织的侵袭和转移、诱导肿瘤细胞凋亡、抑制肿瘤血管生成、调节免疫功能、维持基因组稳定性、防止突变以及调节细胞能量代谢。使用中药产生抗肿瘤作用不仅具有良好的治疗效果且副作用小,还为临床治疗和用药提供了坚实的理论基础。本文基于肿瘤特征综述了中药抗肿瘤作用的机制。通过我们的综述发现,中药不仅直接抑制肿瘤,还增强机体免疫力,从而间接诱导抗肿瘤作用。这一功能符合中医“扶正祛邪”理论。此外,中药在临床肿瘤治疗中将发挥重要作用。

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