Institute of Experimental Medicine, V. A. Almazov National Medical Research Center, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
Bull Exp Biol Med. 2024 Mar;176(5):543-547. doi: 10.1007/s10517-024-06064-5. Epub 2024 May 8.
We studied the dynamics of the main hemodynamic parameters in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats with visceral obesity and chemically induced colitis (CIC) against the background of probiotic therapy. Systolic BP, HR, and body temperature were recorded over 36 days using a wireless telemetry system. During 8 days (3 days before CIC induction and until the end of the experiment) the animals were intragastrically administered a probiotic based on Lactobacillus delbrueckii D5 strain. At baseline, systolic BP was significantly higher in the SHR group, while HR and body temperature did not differ in SHR and WKY rats. On day 8 after CIC induction, systolic BP, HR, and body temperature in SHR were significantly increased in comparison with the initial values. In the group of WKY rats, all indices at the end of the experiment remained at the initial levels. Probiotic therapy in SHR, in contrast to WKY rats, did not lead to normalization of body temperature and hemodynamic disorders resulting from CIC.
我们研究了自发性高血压大鼠（SHR）和内脏肥胖及化学诱导结肠炎（CIC）的 Wistar-Kyoto（WKY）大鼠在益生菌治疗背景下的主要血流动力学参数的动态变化。使用无线遥测系统记录了 36 天的收缩压（SBP）、心率（HR）和体温。在 8 天（CIC 诱导前 3 天至实验结束）期间，动物通过胃内给予基于德氏乳杆菌 D5 株的益生菌。在基线时，SHR 组的收缩压明显升高，而 SHR 和 WKY 大鼠的 HR 和体温没有差异。在 CIC 诱导后第 8 天，与初始值相比，SHR 的收缩压、HR 和体温明显增加。在 WKY 大鼠组，实验结束时所有指标仍保持在初始水平。与 WKY 大鼠相比，益生菌治疗并未使 SHR 的体温和 CIC 引起的血流动力学紊乱正常化。
