Mazziotta J C, Huang S C, Phelps M E, Carson R E, MacDonald N S, Mahoney K
J Cereb Blood Flow Metab. 1985 Mar;5(1):70-8. doi: 10.1038/jcbfm.1985.10.
A technique is described that provides information about relative cerebral responses to differing neurobehavioral tasks in normal subjects studied with positron computed tomography and oxygen-15-labeled water. Simulation studies demonstrate that this technique is sensitive to changes in true local CBF within a physiological range and tends to underestimate relative flow changes at high flow values (greater than 30 ml min-1 100 g-1) and to overestimate these changes for flow values of less than 25 ml min-1 100 g-1. Image acquisition times of 60 s following the arrival of oxygen-15-labeled water in the brain were the most accurate for identifying such relative changes between radioisotope administrations and were not limited by statistical noise from total image counts. Studies in normal volunteers indicate that the technique is highly reproducible, demonstrating a coefficient of variation for small (less than 2 cm2) regions of 2.98 between studies in the same state. Visual stimulation studies in normal volunteers demonstrated relative radioisotope concentration changes between control and stimulated states that are in good agreement with similar results obtained using the same stimulation paradigm but with the use of fluorodeoxyglucose to determine cerebral glucose metabolism.
本文描述了一种技术，该技术可提供有关正常受试者在使用正电子计算机断层扫描和氧-15标记水进行研究时，对不同神经行为任务的相对脑反应的信息。模拟研究表明，该技术对生理范围内真实局部脑血流量（CBF）的变化敏感，在高流量值（大于30 ml·min⁻¹·100 g⁻¹）时往往低估相对流量变化，而在流量值小于25 ml·min⁻¹·100 g⁻¹时则高估这些变化。在氧-15标记水到达大脑后60秒的图像采集时间对于识别放射性同位素给药之间的这种相对变化最为准确，并且不受总图像计数的统计噪声限制。对正常志愿者的研究表明，该技术具有高度可重复性，在相同状态下的研究中，小区域（小于2 cm²）的变异系数为2.98。对正常志愿者的视觉刺激研究表明，对照状态和刺激状态之间的相对放射性同位素浓度变化与使用相同刺激范式但使用氟脱氧葡萄糖来确定脑葡萄糖代谢所获得的类似结果高度一致。
