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α-干扰素的免疫调节作用。I. α-干扰素在体外抑制正常人淋巴细胞的抗体合成。

Immunoregulatory effects of interferon-alpha. I. Interferon-alpha inhibits in vitro antibody synthesis by normal human lymphocytes.

作者信息

Pelton B K, Denman A M

出版信息

Clin Exp Immunol. 1985 Feb;59(2):398-404.

PMID:3872188
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1577144/
Abstract

The effects of human interferon-alpha (IFN-alpha) on in vitro synthesis of specific anti-influenza virus antibody were measured in cultures of peripheral blood lymphocytes from normal donors. IFN-alpha suppressed antibody synthesis in a time and dose related manner. This suppression was also produced by monoclonal antibody purified IFN-alpha and was blocked by anti-IFN-alpha antibody. However antibody induced by a combination of antigen and 'B cell helper supernatant' was not suppressed indicating that IFN-alpha inhibits the initial events in antibody synthesis but does not affect cells committed to antibody production.

摘要

在正常供体的外周血淋巴细胞培养物中，检测了人α干扰素（IFN-α）对特异性抗流感病毒抗体体外合成的影响。IFN-α以时间和剂量相关的方式抑制抗体合成。这种抑制作用也由单克隆抗体纯化的IFN-α产生，并被抗IFN-α抗体阻断。然而，由抗原和“B细胞辅助上清液”组合诱导的抗体未被抑制，这表明IFN-α抑制抗体合成的起始事件，但不影响已致力于抗体产生的细胞。

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J Immunol. 1981 Nov;127(5):1852-6.
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Induction of immunoglobulin and antigen-dependent antibody synthesis in human lymphocytes, using supernatants from mitogen-stimulated cultures.利用丝裂原刺激培养物的上清液诱导人淋巴细胞中免疫球蛋白和抗原依赖性抗体的合成。
Immunology. 1983 Jan;48(1):157-63.
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Immuno-modulating properties of interferons.
Philos Trans R Soc Lond B Biol Sci. 1982 Sep 24;299(1094):77-90. doi: 10.1098/rstb.1982.0108.
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