Pelton B K, Denman A M
Clin Exp Immunol. 1985 Feb;59(2):398-404.
The effects of human interferon-alpha (IFN-alpha) on in vitro synthesis of specific anti-influenza virus antibody were measured in cultures of peripheral blood lymphocytes from normal donors. IFN-alpha suppressed antibody synthesis in a time and dose related manner. This suppression was also produced by monoclonal antibody purified IFN-alpha and was blocked by anti-IFN-alpha antibody. However antibody induced by a combination of antigen and 'B cell helper supernatant' was not suppressed indicating that IFN-alpha inhibits the initial events in antibody synthesis but does not affect cells committed to antibody production.
在正常供体的外周血淋巴细胞培养物中,检测了人α干扰素(IFN-α)对特异性抗流感病毒抗体体外合成的影响。IFN-α以时间和剂量相关的方式抑制抗体合成。这种抑制作用也由单克隆抗体纯化的IFN-α产生,并被抗IFN-α抗体阻断。然而,由抗原和“B细胞辅助上清液”组合诱导的抗体未被抑制,这表明IFN-α抑制抗体合成的起始事件,但不影响已致力于抗体产生的细胞。